Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging.
Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging.
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卵巢的清晰细胞癌：254例完全手术分期的患者的回顾性多中心经验。
DOI：
10.1038/sj.bjc.6603116
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发表时间：
2006-05-22
影响因子：
8.8
通讯作者：
Sugiyama, T.
中科院分区：
文献类型：
--
作者：
Takano, M.;Kikuchi, Y.;Yaegashi, N.;Kuzuya, K.;Ueki, M.;Tsuda, H.;Suzuki, M.;Kigawa, J.;Takeuchi, S.;Tsuda, H.;Moriya, T.;Sugiyama, T.
回顾性分析卵巢透明细胞癌（CCC）患者的临床特征和预后因素。经过对9家日本机构1992年至2003年间的病历进行中央病理审查和扫描后，共有254名卵巢CCC患者被纳入本研究。平均年龄为 52.4 岁（范围 23-73 岁）。肿瘤为 Ia 期的比例为 13% (33/254)，Ic 期的比例为 36% (92/254)，II 期的比例为 13% (33/254)，III 期的比例为 30% (80/254)，IV 期的比例为 6% (16/254)。 I期的五年无进展生存率和总生存率分别为84%和88%，II期为57%和70%，III期为25%和33%，IV期为0%和0%。 pT1a肿瘤中观察到腹膜后淋巴结转移，pT1c肿瘤中观察到7%，pT2肿瘤中13%，pT3肿瘤中58%。根据接受完整手术分期程序和常规化疗的患者的化疗差异，没有生存获益。腹膜细胞学状态是Ic期患者的独立预后因素（P=0.03），仅残留肿瘤直径是III、IV期患者的独立预后因素（P=0.02）。我们的结果表明，无残留肿瘤的细胞减灭术只能改善晚期 CCC 患者的预后。
A retrospective analysis was performed to evaluate the clinical characteristics and prognostic factors in the patients with clear cell carcinoma (CCC) of the ovary. After central pathological review and scanning of the medical records of nine Japanese institutions between 1992 and 2003, a total of 254 patients with CCC of the ovary were enrolled in the present study. Mean age was 52.4 years (range 23–73 years). Tumours were 13% (33/254) stage Ia, 36% (92/254) stage Ic, 13% (33/254) stage II, 30% (80/254) stage III, and 6% (16/254) stage IV. Five-year progression-free survival and overall survival was 84 and 88% in stage I, 57 and 70% in stage II, 25 and 33% in stage III and 0 and 0% in stage IV, respectively. Retroperitoneal lymph node metastasis was observed in 9% in pT1a tumours, 7% in pT1c tumours, 13% in pT2 tumours, and 58% in pT3 tumours, respectively. There was no survival benefit according to chemotherapeutic differences in the patients who received complete surgical staging procedures and conventional chemotherapy. Peritoneal cytological status was an independent prognostic factor in stage Ic patients (P=0.03) and only residual tumour diameter was an independent prognostic factor in stage III, IV patients (P=0.02). Our results suggest that cytoreductive surgery resulting in no residual tumour only could improve the prognosis of advanced CCC patients.
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DOI：
10.1111/j.1349-7006.2002.tb01312.x
发表时间：
2002-06
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Itamochi H;Kigawa J;Sultana H;Iba T;Akeshima R;Kamazawa S;Kanamori Y;Terakawa N
通讯作者：
Terakawa N
影响因子：
3.5
作者：
Mizuno, M;Kikkawa, F;Mizutani, S
通讯作者：
Mizutani, S
影响因子：
4.7
作者：
Cass, I;Li, AJ;Karlan, BY
通讯作者：
Karlan, BY
影响因子：
5.6
作者：
Leitao, MM;Boyd, J;Soslow, RA
通讯作者：
Soslow, RA
影响因子：
4.7
作者：
OBRIEN, MER;SCHOFIELD, JB;WILTSHAW, E
通讯作者：
WILTSHAW, E