The Evolution of the Ribosomal Protein-MDM2-p53 Pathway.
The Evolution of the Ribosomal Protein-MDM2-p53 Pathway.
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DOI：
10.1101/cshperspect.a026138
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发表时间：
2016-12-01
影响因子：
5.4
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Deisenroth C;Franklin DA;Zhang Y
在过去的几十年里，我们对核糖体蛋白作为核糖体静态构建模块的理解不断发展到高度集成的 p53 监视和功能传感器，取得了巨大的进展。作为细胞的主力，核糖体负责将遗传密码翻译成驱动细胞生长和增殖的功能单元。核糖体蛋白与 MDM2（p53 的负调节因子）结合的开创性鉴定，已发展成为核糖体蛋白-MDM2-p53 信号传导的范例，该信号传导延伸到从能量代谢到增殖等多种过程。当 rRNA 合成、加工和组装的扰动调节核糖体生物合成速率时，信号传导的核心就会发生，从而发出对 p53 的核仁应激反应信号。这导致了许多与核糖体蛋白功能障碍相关的疾病病理的鉴定，这些疾病病理表现为发育障碍或癌症。推进对核糖体蛋白 - MDM2 - p53 信号传导基本机制的研究，为核糖体相关疾病的生物标志物识别和治疗策略的新型转化研究铺平了道路。
The progression of our understanding of ribosomal proteins as static building blocks of the ribosome to highly integrated sensors of p53 surveillance and function has achieved a tremendous rate of growth over the past several decades. As the workhorse of the cell, ribosomes are responsible for translating the genetic code into the functional units that drive cell growth and proliferation. The seminal identification of ribosomal protein binding to MDM2, the negative regulator of p53, has evolved into a paradigm for ribosomal protein–MDM2–p53 signaling that extends into processes as diverse as energy metabolism to proliferation. The central core of signaling occurs when perturbations to rRNA synthesis, processing, and assembly modulate the rate of ribosome biogenesis, signaling a nucleolar stress response to p53. This has led to identification of a number of disease pathologies related to ribosomal protein dysfunction that are manifested as developmental disorders or cancer. Advancing research into the basic mechanics of ribosomal protein–MDM2–p53 signaling is paving the way for novel translational research into biomarker identification and therapeutic strategies for ribosome-related diseases.
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影响因子：
3.9
作者：
Boria, Ilenia;Garelli, Emanuela;Gazda, Hanna T.;Aspesi, Anna;Quarello, Paola;Pavesi, Elisa;Ferrante, Daniela;Meerpohl, Joerg J.;Kartal, Mutlu;Da Costa, Lydie;Proust, Alexis;Leblanc, Thierry;Simansour, Maud;Dahl, Niklas;Froejmark, Anne-Sophie;Pospisilova, Dagmar;Cmejla, Radek;Beggs, Alan H.;Sheen, Mee R.;Landowski, Michael;Buros, Christopher M.;Clinton, Catherine M.;Dobson, Lori J.;Vlachos, Adrianna;Atsidaftos, Eva;Lipton, Jeffrey M.;Ellis, Steven R.;Ramenghi, Ugo;Dianzani, Irma
通讯作者：
Dianzani, Irma
影响因子：
4.8
作者：
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通讯作者：
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影响因子：
64.8
作者：
Ebert, Benjamin L.;Pretz, Jennifer;Bosco, Jocelyn;Chang, Cindy Y.;Tamayo, Pablo;Galili, Naomi;Raza, Azra;Root, David E.;Attar, Eyal;Ellis, Steven R.;Golub, Todd R.
通讯作者：
Golub, Todd R.
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影响因子：
8
作者：
Cui, D.;Li, L.;Tang, J.
通讯作者：
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影响因子：
5.3
作者：
Dai, MS;Zeng, SX;Lu, H
通讯作者：
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