Prognostic significance of 11q23 aberrations in adult acute myeloid leukemia and the role of allogeneic stem cell transplantation.
Prognostic significance of 11q23 aberrations in adult acute myeloid leukemia and the role of allogeneic stem cell transplantation.
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作者：
将148例11q23染色体异常的急性髓性白血病（AML）患者与2640例非11q23染色体异常的AML患者的临床特征和结局进行比较。t(9;11))、t（6;11）或其他11q23平衡易位[t(11;v)(q23;v)]的患者年龄较轻，骨髓原细胞百分比较高。不平衡的11q23异常通常与染色体5q、7q和/或复杂核型的缺失有关。在多因素分析中，与非11q23 AML和不良风险核型患者相比，t（9;11）患者的总生存期（OS）有显著差异（P = 0.004），而t(6;11) （P = 0.62）、t(11;19) （P = 0.20）、不平衡11q23畸变（P = 0.85）或t(11;v)(q23;v) （P = 0.59）患者的总生存期（OS）无差异，表明t（9;11）具有独立的中间预后因素，所有其他不良预后因素均影响OS；通过将他们与非11q23 AML和中间风险核型患者进行比较，进一步证实了这一点。使用基于供体可用性的意向治疗分析，我们还注意到，首次缓解的同种异体干细胞移植（SCT）对改善AML和11q23异常患者的OS （P<0.001）和无复发生存率（P<0.001）有显著益处。
The clinical features and outcomes of 148 patients with acute myeloid leukemia (AML) and 11q23 chromosomal abnormalities were compared with those of 2640 patients with non-11q23 AML. Patients with t(9;11)), t(6;11), or other 11q23 balanced translocations [t(11;v)(q23;v)] presented at a younger age and with higher percentage of bone marrow blasts. Unbalanced 11q23 abnormalities were commonly associated with deletions of chromosomes 5q, 7q and/or complex karyotypes. In multivariate analysis, when compared to patients with non-11q23 AML and unfavorable risk karyotype, there was a significant difference in overall survival (OS) for patients with t(9;11) (P = .004), whereas there were no difference in OS for patients with t(6;11) (P = .62), t(11;19) (P = 0.20), and unbalanced 11q23 aberrations (P = .85) or t(11;v)(q23;v) (P = 0.59), indicating that t(9;11) has an independent intermediate prognostic factor, with all others poor prognostic factors for OS; this was further confirmed by comparing them with patients with non-11q23 AML and intermediate risk karyotype. Using intention-to treat analysis based on donor availability, we also noted that allogeneic stem cell transplant (SCT) in first remission had a significant benefit towards improving OS (P < 0.001) and relapse-free survival (P<0.001) in patients with AML and 11q23 abnormalities.
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影响因子：
11.4
作者：
Meyer, C.;Kowarz, E.;Marschalek, R.
通讯作者：
Marschalek, R.
影响因子：
11.4
作者：
Goemans, BF;Zwaan, CM;Heinrich, MC
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Heinrich, MC
影响因子：
20.3
作者：
Gupta, Vikas;Tallman, Martin S.;Weisdorf, Daniel J.
通讯作者：
Weisdorf, Daniel J.
影响因子：
120.7
作者：
Koreth, John;Schlenk, Richard;Kopecky, Kenneth J.;Honda, Sumihisa;Sierra, Jorge;Djulbegovic, Benjamin J.;Wadleigh, Martha;DeAngelo, Daniel J.;Stone, Richard M.;Sakamaki, Hisashi;Appelbaum, Frederick R.;Doehner, Hartmut;Antin, Joseph H.;Soiffer, Robert J.;Cutler, Corey
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Cutler, Corey
影响因子：
45.3
作者：
PUI, CH;BEHM, FG;RAIMONDI, SC
通讯作者：
RAIMONDI, SC