Dementia and Disability: Impact on Mortality
Dementia and Disability: Impact on Mortality
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痴呆症和残疾：对死亡率的影响
DOI：
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发表时间：
2003
影响因子：
2.4
通讯作者：
Gaetano Crepaldi
中科院分区：
文献类型：
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作者：
M. Noale;S. Maggi;Nadia Minicuci;C. Marzari;C. Destro;Gino Farchi;E. Scafato;M. Baldereschi;A. D. Carlo;Gaetano Crepaldi
众所周知，痴呆症与死亡率过高有关。身体残疾作为痴呆症严重程度的标志，通常被认为是从疾病到死亡的最后一步。本研究的目的是在意大利进行的一项基于人群的研究中调查痴呆对死亡率的直接影响，样本为5，632名65-84岁的个体。在4年的随访中，998名参与者死亡。死亡的独立预测因素是：年龄（75-84岁; HR 2.63，CI = 2.11-3.27），男性（HR 1.45，CI = 1.22-1.74），冠心病（HR 1.61，CI = 1.34-1.94），中重度工具性日常生活活动能力障碍（HR 1.98，CI = 1.30-3.03和HR 3.26，CI = 2.09-5.09），生存期大于23个月的受试者中的糖尿病（HR 0.68，CI = 0.43-1.08）和痴呆（HR 2.07，CI = 1.62-2.66）。这些数据提供的证据表明，痴呆本身，独立于身体残疾，是老年人死亡的一个强有力的预测因素。
Dementia is known to be associated with excess mortality. Physical disability, as a marker of dementia severity, is often considered the last step on the way from disease to death. The objective of this study was to investigate the direct effect of dementia on mortality in a population-based study, carried out in Italy, with a sample of 5,632 individuals aged 65–84 years. At 4-year follow-up, 998 participants had died. The independent predictors of death were: age (75–84 years; HR 2.63, CI = 2.11–3.27), male sex (HR 1.45, CI = 1.22–1.74), coronary heart disease (HR 1.61, CI = 1.34–1.94), moderate and severe instrumental activities of daily living disability (HR 1.98, CI = 1.30–3.03 and HR 3.26, CI = 2.09–5.09, respectively), diabetes in subjects with a survival time greater than 23 months (HR 0.68, CI = 0.43–1.08) and dementia (HR 2.07, CI = 1.62–2.66). These data provide evidence that dementia per se, independently from physical disability, is a strong predictor of death in the elderly.
美国因阿尔茨海默病死亡的人数。
影响因子：
12.7
作者：
Ewbank,DC
通讯作者：
Ewbank,DC
影响因子：
12.7
作者：
KELMAN, HR;THOMAS, C;CHENG, JM
通讯作者：
CHENG, JM
影响因子：
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作者：
KATZMAN, R;HILL, LR;ZHANG, MY
通讯作者：
ZHANG, MY