NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target.
NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target.
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DOI：
10.2741/3782
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Lin Y
中科院分区：
文献类型：
--
作者：
Chen W;Li Z;Bai L;Lin Y
肺癌是全球第一位恶性肿瘤杀手。尽管烟草烟雾和环境中的致癌物是肺癌的主要原因，但肺癌发生的机制仍然难以捉摸。癌症的发展和进展取决于细胞存活和死亡信号之间的平衡。常见的细胞存活信号传导途径被致癌物以及炎性细胞因子激活，这在很大程度上促进了癌症的发展。核因子-κ B（nuclear factor-kappaB，NF-kappaB）作为一种重要的细胞存活信号，参与肿瘤发生的多个步骤，并参与肿瘤细胞对化疗和放疗的抵抗。最近的动物模型和细胞培养系统的研究已经建立了NF-kappaB和肺癌发生之间的联系，突出了靶向NF-kappaB信号通路对肺癌治疗和化学预防的意义。本文就NF-kappaB通路在肺癌发生发展中的作用以及调节NF-kappaB通路在肺癌预防和治疗中的研究进展作一综述。
Lung cancer ranks as the first malignant tumor killer worldwide. Despite the knowledge that carcinogens from tobacco smoke and the environment constitute the main causes of lung cancer, the mechanisms for lung carcinogenesis are still elusive. Cancer development and progression depend on the balance between cell survival and death signals. Common cell survival signaling pathways are activated by carcinogens as well as by inflammatory cytokines, which contribute substantially to cancer development. As a major cell survival signal, nuclear factor-kappaB (NF-kappaB) is involved in multiple steps in carcinogenesis and in cancer cell’s resistance to chemo- and radiotherapy. Recent studies with animal models and cell culture systems have established the links between NF-kappaB and lung carcinogenesis, highlighting the significance of targeting the NF-kappaB signaling pathway for lung cancer treatment and chemoprevention. In this review, we summarize progresses in understanding the NF-kappaB pathway in lung cancer development as well as in modulating NF-kappaB for lung cancer prevention and therapy.
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