Travelling and splitting of a wave of hedgehog expression involved in spider-head segmentation.
Travelling and splitting of a wave of hedgehog expression involved in spider-head segmentation.
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DOI：
10.1038/ncomms1510
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发表时间：
2011-10-11
影响因子：
16.6
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中科院分区：
文献类型：
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在发育过程中，分割是一个产生空间周期性模式的过程。基因表达波的峰分裂是一种数学预测的简单策略，可以解释这种类型的过程，但它还没有得到很好的生物学表征。在这里，我们展示了在蜘蛛Achaearanea胚胎中与头轴生长相关的基因表达的时间重复分裂成条纹。在分割之前，观察到刺猬同源基因表达的波在发育阶段6期间向后行进。这条，共同表达一个orthodenticle同源，经历了两个周期的分裂和转移伴随着收敛扩展，作为一个生殖区的头部部分。这两个orthodenticle和奇数配对的同源物被确定为刺猬信号的目标，和证据表明，他们的活动介导反馈，以维持头部生成区，并促进条纹分裂在这个区域。我们建议，“条纹分裂”的战略采用共享的遗传成分与果蝇胚盘细分，这是需要参与一个autoregulatory信号网络。在发育过程中，体轴的分割需要基因表达的波动。在这项研究中，刺猬基因表达的一个波的重复分裂显示在分割的蜘蛛Achaearanea tepidariorum。
During development segmentation is a process that generates a spatial periodic pattern. Peak splitting of waves of gene expression is a mathematically predicted, simple strategy accounting for this type of process, but it has not been well characterized biologically. Here we show temporally repeated splitting of gene expression into stripes that is associated with head axis growth in the spider Achaearanea embryo. Preceding segmentation, a wave of hedgehog homologue gene expression is observed to travel posteriorly during development stage 6. This stripe, co-expressing an orthodenticle homologue, undergoes two cycles of splitting and shifting accompanied by convergent extension, serving as a generative zone for the head segments. The two orthodenticle and odd-paired homologues are identified as targets of Hedgehog signalling, and evidence suggests that their activities mediate feedback to maintain the head generative zone and to promote stripe splitting in this zone. We propose that the 'stripe-splitting' strategy employs genetic components shared with Drosophila blastoderm subdivision, which are required for participation in an autoregulatory signalling network. During development, waves of gene expression are required for segmentation of the body axis. In this study, repeated splitting of a wave of hedgehog gene expression is shown during segmentation of the spider Achaearanea tepidariorum.
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作者：
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