Clinical significance and prevalence of anti-Saccharomyces cerevisiae antibody in Chinese patients with primary biliary cirrhosis
Clinical significance and prevalence of anti-Saccharomyces cerevisiae antibody in Chinese patients with primary biliary cirrhosis
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中国原发性胆汁性肝硬化患者抗酿酒酵母抗体的临床意义及患病率
DOI：
10.1007/s10238-012-0207-4
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发表时间：
2013-11
影响因子：
4.6
通讯作者：
Hu C, Deng C, Zhang S, Song G, Li L, Li X, Wang L,
中科院分区：
文献类型：
--
作者：
Hu C, Deng C, Zhang S, Song G, Li L, Li X, Wang L,
抗酿酒酵母抗体(ASCA)的临床意义及其在中国原发性胆汁性肝硬变(PBC)患者中的患病率尚未确定，因此需要明确。采用酶联免疫吸附试验检测198例PBC患者、85例其他肝病患者(老年组)和35例健康对照组(HC组)的血清ASCA水平。采用间接免疫荧光法检测PBC中抗线粒体抗体(AMA)。结果表明，PBC中ASCA的发生率为29.8%，高于其他疾病组。抗gp210抗体阳性的PBC患者ASCA发生率高于抗gp210抗体阴性的PBC患者。在AMA阴性的15例PBC中，有7例ASCA阳性。ASCA阳性的PBC患者部分肝脏相关生化指标和炎症指标明显升高(P<；P<0.05)。综上所述，中国PBC患者ASCA患病率为29.8%。ASCA阳性的PBC患者肝损害程度较重，ASCA-IgA可能与PBC的疾病活动性有关。
Clinical significance of anti-Saccharomyces cerevisiae antibody (ASCA) and its prevalence in Chinese primary biliary cirrhosis (PBC) patients have not been characterized and therefore needs to be defined. Enzyme-linked immunosorbent assay was used to test ASCA in sera from 198 PBC patients, 85 patients with other liver diseases (OLD) and 35 health controls (HC). Indirect immunofluorescence was used to detect anti-mitochondrial antibodies (AMA) in PBC. Results showed that the frequency of ASCA in PBC, 29.8 %, was higher than other disease groups. And ASCA occurred more frequently in PBC patients with positive anti-gp210 than the negative ones. Also, ASCA was detected in 7 out of 15 PBC negative for AMA. Some liver-related biochemical indices and inflammatory indices were significantly higher in PBC patients with positive ASCA (p< 0.05). In conclusion, the prevalence of ASCA in Chinese PBC patients is 29.8 %. PBC patients with positive ASCA are associated with more severe liver injury, and ASCA-IgA might be related to disease activity of PBC.
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影响因子：
13.5
作者：
Nakamura, Minoru;Kondo, Hisayoshi;Ishibashi, Hiromi
通讯作者：
Ishibashi, Hiromi
影响因子：
4.6
作者：
Muratori, P;Muratori, L;Bianchi, FB
通讯作者：
Bianchi, FB
DOI：
10.1074/jbc.m003140200
发表时间：
2000-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
E. Cabiscol;Eva Piulats;P. Echave;E. Herrero;J. Ros
通讯作者：
E. Cabiscol;Eva Piulats;P. Echave;E. Herrero;J. Ros
DOI：
--
发表时间：
2009-03
期刊：
Minerva gastroenterologica e dietologica
影响因子：
--
作者：
S. Fagoonee;L. Deluca;C. DeAngelis;A. Castelli;M. Rizzetto;R. Pellicano
通讯作者：
S. Fagoonee;L. Deluca;C. DeAngelis;A. Castelli;M. Rizzetto;R. Pellicano
影响因子：
3.1
作者：
Hu, Chaojun;Deng, Chuiwen;Li, Yongzhe
通讯作者：
Li, Yongzhe