Examining Associations Between Baseline Health-Related Quality of Life and Depression and Physical Functioning Improvement Following Pulmonary Rehabilitation.

Examining Associations Between Baseline Health-Related Quality of Life and Depression and Physical Functioning Improvement Following Pulmonary Rehabilitation.
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检查基线健康相关生活质量与抑郁症和肺康复后身体功能改善之间的关联。

DOI:
10.1097/hcr.0000000000000844
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发表时间:
2024
影响因子:
3.8
通讯作者:
Gaalema,DiannE
Gaalema,DiannE
中科院分区:
医学3区
文献类型:
--
作者:
Coleman,SulamunnRM;Menson,KatherineE;Katz,BrianR;DeSarno,MichaelJ;Gaalema,DiannE

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目的:本研究探讨是否健康相关的生活质量(HRQL)和抑郁症评估之前,肺康复(PR)的参与(即,在基线)预测6分钟步行距离(6 MWD)从基线到结束的PR.Methods的变化:肺部疾病患者连续转介/登记在PR程序从2009年至2022年(N= 503)。使用HRQL(St乔治呼吸问卷[SGRQ])和抑郁(老年抑郁量表[GDS])的自我报告测量值对基线6 MWD进行沿着评估。SGRQ总分用于评估总体HRQL,SGRQ分量表评估肺部症状、活动限制和肺部疾病的心理社会影响。结果:基线SGRQ总分(F(1,389)= 8.4,P=. 0001)与基线SGRQ总分(F(1,389)=. 0001)比较,差异有统计学意义(P < 0. 05)。004)活动受限(F(1,388)= 4.8,P=. 03)预测Δ 6 MWD。SGRQ活动受限评分≤第25百分位数的患者显示出最大的6 MWD改善(平均值= 79.7 m,SE= 6.7),并且显著高于评分在第50- 75百分位数之间(平均值= 54.4 m,SE= 6.0)或>第75百分位数(平均值= 48.7 m,SE= 7.5)的参与者。第25- 50次评分之间的患者(平均值= 70.2 m,SE= 6.1)与其他组无显著差异。SGRQ症状和影响分量表与Δ 6 MWD无关(F(1,388)= 1.2-1.9,P> 0.05)。抑郁症(F(1,311)= 0.0,P> 0.05)。结论:基线时HRQL较高的患者在PR后可能会经历更大的身体功能改善。对HRQL较低的患者的额外支持(例如,积极的自我管理干预)可能会提高PR结局,特别是对报告活动受限较大的患者。或者,早期转诊至PR(即症状较轻时)也可能有益于身体功能结局。
Purpose:This study examined whether health-related quality of life (HRQL) and depression assessed prior to pulmonary rehabilitation (PR) participation (ie, at baseline) predicted change in 6-min walk distance (6MWD) from baseline to end of PR.Methods:Patients with pulmonary disease were consecutively referred/enrolled in a PR program from 2009-2022 (N= 503). Baseline 6MWD was assessed along with self-report measures of HRQL (St George’s Respiratory Questionnaire [SGRQ]) and depression (Geriatric Depression Scale [GDS]). The SGRQ total score was used to assess overall HRQL, and SGRQ subscales assessed pulmonary symptoms, activity limitations, and psychosocial impacts of pulmonary disease. Multiple linear regression was used to examine whether baseline SGRQ scores and depression predicted Δ6MWD.Results:Baseline SGRQ total score (F (1,389)= 8.4, P=. 004) and activity limitations (F (1,388)= 4.8, P=. 03) predicted Δ6MWD. Patients with an SGRQ activity limitation score≤ 25th percentile showed the most 6MWD improvement (mean= 79.7 m, SE= 6.7), and significantly more improvement than participants scoring between the 50-75th percentiles (mean= 54.4 m, SE= 6.0) or> 75th percentile (mean= 48.7 m, SE= 7.5). Patients scoring between the 25-50th percentiles (mean= 70.2 m, SE= 6.1) did not differ significantly from other groups. The SGRQ symptoms and impacts subscales were unrelated to Δ6MWD (F (1,388)= 1.2-1.9, P>. 05), as was depression (F (1,311)= 0.0, P>. 85).Conclusions:Patients with greater HRQL at baseline may experience greater physical functioning improvement following PR. Additional support for patients with lower HRQL (eg, adjunctive self-management interventions) may enhance PR outcomes, particularly for patients who report greater activity limitations. Alternatively, early referral to PR (ie, when less symptomatic) may also benefit physical function outcomes.
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