Serum Squamous Cell Carcinoma Antigen in Psoriasis: A Potential Quantitative Biomarker for Disease Severity
Serum Squamous Cell Carcinoma Antigen in Psoriasis: A Potential Quantitative Biomarker for Disease Severity
复制标题
银屑病血清鳞状细胞癌抗原：疾病严重程度的潜在定量生物标志物
作者：
Sun ZW;Shi XM;Wang Y;Zhao Y
背景资料：客观、定量地评价银屑病的严重程度，对于银屑病的精准护理实践和研究具有重要意义。目的：我们的目的是探讨定量与银屑病患者的疾病严重程度和治疗反应相关的血清生物标志物，在这项初步研究中评估了血清鳞状细胞癌抗原（SCCA）。方法：对15例银屑病患者进行阿达木单抗治疗。在治疗前后的不同访视中，从患者的标准化数字身体图像中获得定量体表面积（qBSA），并监测银屑病面积严重程度指数（PASI）。采用微粒子酶免疫法检测SCCA。在健康志愿者中检测血清生物标志物作为正常对照。采用受试者工作特征（ROC）曲线分析探讨SCCA鉴别轻、中重度银屑病的最佳分界点。结果：银屑病组血清SCCA水平明显高于正常对照组（P < 0.05）。治疗后血清SCCA水平明显下降（p < 0.05）。SCCA水平与PASI、qBSA呈显著正相关。在ROC分析中，以PASI = 10或qBSA = 10%为阈值时，SCCA的最佳截断点为2.0 ng/mL，Youden指数最高。结论：血清SCCA可作为银屑病病情严重程度的定量生物标志物。
Background: An objective and quantitative method to evaluate psoriasis severity is important for practice and research in the precision care of psoriasis. Objectives: We aimed to explore serum biomarkers quantitatively in association with disease severity and treatment response in psoriasis patients, with serum squamous cell carcinoma antigen (SCCA) evaluated in this pilot study. Methods: 15 psoriasis patients were treated with adalimumab. At different visits before and after treatment, quantitative body surface area (qBSA) was obtained from standardized digital body images of the patients, and the psoriasis area severity index (PASI) was also monitored. SCCA were detected by using microparticle enzyme immunoassay. The serum biomarkers were also tested in healthy volunteers as normal controls. Receiver-operating characteristic (ROC) curve analysis was used to explore the optimal cutoff point of SCCA to differentiate mild and moderate-to-severe psoriasis. Results: The serum SCCA level in the psoriasis group was significantly higher (p < 0.05) than in the normal control group. After treatment, the serum SCCA levels were significantly decreased (p < 0.05). The SCCA level was well correlated with PASI and qBSA. In ROC analysis, when taking PASI = 10 or qBSA = 10% as the threshold, an optimal cutoff point of SCCA was found at 2.0 ng/mL with the highest Youden index. Conclusion: Serum SCCA might be a useful quantitative biomarker for psoriasis disease severity.
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DOI：
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期刊：
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作者：
通讯作者：
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影响因子：
82.9
作者：
Chen, Chun-Jen;Kono, Hajime;Rock, Kenneth L.
通讯作者：
Rock, Kenneth L.
影响因子：
4
作者：
Lian, Fan;Wang, Yu;Liang, Liuqin
通讯作者：
Liang, Liuqin
影响因子：
5.9
作者：
Nishi, N;Miyazaki, M;Hamasaki, Y
通讯作者：
Hamasaki, Y
影响因子：
2
作者：
H. Kato
通讯作者：
H. Kato