The spectrum of vaccine therapies for patients with glioblastoma multiforme.
The spectrum of vaccine therapies for patients with glioblastoma multiforme.
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多形胶质母细胞瘤患者的疫苗疗法谱。
DOI：
10.1007/s11864-012-0208-2
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发表时间：
2012-12
影响因子：
4.3
通讯作者：
Chiocca, E. Antonio
中科院分区：
文献类型：
--
作者：
Aguilar, Laura K.;Arvizu, Mariel;Aguilar-Cordova, Estuardo;Chiocca, E. Antonio
Glioblastoma multiforme (GBM) is the most common primary malignant tumor of the central nervous system (CNS) and one of the most lethal cancers in adults and children. Despite aggressive treatment with surgery, radiation, and chemotherapy, median survival is less than 15 months and overall survival is less than 10 % at 5 years. Development of therapeutics for malignant gliomas has been hampered by their natural complexity as well as protective mechanisms unique to the CNS. Better understanding of the pathogenesis of GBM is opening the path to novel, specific-targeted therapies. Recently, multiple immunotherapy approaches have been acquiring substantial indication of therapeutic efficacy with a very safe profile. Examples of the leading clinical approaches for GBM will be discussed in detail in this review.
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DOI：
10.3747/co.2007.147
发表时间：
2007-10-01
期刊：
Current oncology (Toronto, Ont.)
影响因子：
--
作者：
Perry, J;Chambers, A;Laperriere, N
通讯作者：
Laperriere, N
DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
45.3
作者：
Hegi, Monika E.;Liu, Lili;Gilbert, Mark R.
通讯作者：
Gilbert, Mark R.
影响因子：
158.5
作者：
Kantoff, Philip W.;Higano, Celestia S.;Young, J.
通讯作者：
Young, J.
影响因子：
--
作者：
Jackson C;Ruzevick J;Phallen J;Belcaid Z;Lim M
通讯作者：
Lim M