Minireview: the year in review of estrogen regulation of metabolism.

Minireview: the year in review of estrogen regulation of metabolism.
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DOI:
10.1210/me.2012-1284
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发表时间:
2012-12
期刊:
Molecular endocrinology (Baltimore, Md.)
影响因子:
--
通讯作者:
Clegg DJ
Clegg DJ
中科院分区:
其他
文献类型:
--
作者:
Clegg DJ

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性腺类固醇是生理的关键调节器,然而我们用最简单的视角/模型——男性视角——来研究生理和科学。整个动物生理的雌性模型研究起来很复杂,因此通常不用于研究。雌激素是一种性激素,我们知道它对男性和女性都很重要。雌激素调节代谢的关键特征,如食物摄入、体重、葡萄糖稳态/胰岛素敏感性、体脂肪分布、脂肪分解/脂肪生成、炎症、运动活动、能量消耗、生殖和认知。此外,雌激素具有多个作用位点,包括一些意想不到的作用位点,这在今年的一系列论文中得到了很好的证明。
Gonadal steroids are critical regulators of physiology, yet we approach physiology and science with the simplest perspective/model, the male one. Female models of whole animal physiology are complex to study and, therefore, are often not used in research. Estrogens are one of the sex hormones that we know are important for both men and women. Estrogens regulate key features of metabolism such as food intake, body weight, glucose homeostasis/insulin sensitivity, body fat distribution, lipolysis/lipogenesis, inflammation, locomotor activity, energy expenditure, reproduction, and cognition. Furthermore, estrogens have multiple sites of action including some unexpected ones, which was demonstrated elegantly through a series of papers this year.
DOI: 10.1016/j.cmet.2011.09.003
发表时间: 2011-10-05
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影响因子: 29
作者:
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