The influence of gut microbiota on drug metabolism and toxicity.
The influence of gut microbiota on drug metabolism and toxicity.
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DOI：
10.1517/17425255.2016.1121234
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发表时间：
2016
影响因子：
4.3
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Li H;He J;Jia W
肠道微生物群在药物代谢中发挥着关键作用。肠道微生物群的个体差异导致了药物治疗的个体差异，包括药物引起的毒性和疗效。因此，研究和阐明肠道微生物对药物代谢和毒性的影响不仅有助于个体化医疗的发展，而且有助于提高合理的药物设计。该综述概述了微生物群-宿主共代谢对药物代谢的影响，并总结了30种由宿主和肠道微生物群共代谢的临床药物。此外，本综述还专门阐明了肠道微生物对一些临床药物的调节作用，其中深入讨论了肠道微生物对药物代谢、药物引起的毒性和疗效的影响。肠道微生物对药物代谢和毒性的贡献日益得到认可，但由于肠道微生物群与宿主之间极其复杂的关系，很大程度上仍未得到探索。阐明肠道菌群在药物代谢中的作用机制是通过调节人体肠道菌群在药物设计或个性化医疗方面取得实际进展的关键，而这主要依赖于宏基因组学、代谢组学等技术创新以及多学科知识的整合。
Gut microbiota plays critical roles in drug metabolism. The individual variation of gut microbiota contributes to the interindividual differences towards drug therapy including drug-induced toxicity and efficacy. Accordingly, the investigation and elucidation of gut microbial impacts on drug metabolism and toxicity will not only facilitate the way of personalized medicine, but also improve the rational drug design. This review provide an overview on the microbiota-host cometabolism on drug metabolism and summarize 30 clinical drugs which are co-metabolized by host and gut microbiota. Moreover, this review is specifically focused on elucidating the gut microbial modulation on some clinical drugs, in which the gut microbial influences on drug metabolism, drug-induced toxicity and efficacy are intensively discussed. The gut microbial contribution to drug metabolism and toxicity is increasingly recognized, but remains largely unexplored due to the extremely complex relationship between gut microbiota and host. The mechanistic elucidation of gut microbiota in drug metabolism is critical before any practical progress in drug design or personalized medicine could be made by modulating human gut microbiota, which is predominantly relied on the technical innovations such as metagenomics and metabolomics, as well as the integration of multi-disciplinary knowledge.
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影响因子：
--
作者：
Aura, Anna-Marja;Mattila, Ismo;Oksman-Caldentey, Kirsi-Marja
通讯作者：
Oksman-Caldentey, Kirsi-Marja
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
影响因子：
50.3
作者：
Dapito DH;Mencin A;Gwak GY;Pradere JP;Jang MK;Mederacke I;Caviglia JM;Khiabanian H;Adeyemi A;Bataller R;Lefkowitch JH;Bower M;Friedman R;Sartor RB;Rabadan R;Schwabe RF
通讯作者：
Schwabe RF
影响因子：
5.4
作者：
Ghiringhelli, F;Larmonier, N;Martin, F
通讯作者：
Martin, F
影响因子：
5.8
作者：
Basit, AW;Newton, JM;Lacey, LF
通讯作者：
Lacey, LF