Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response.
Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response.
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DOI：
10.1016/j.brainres.2009.09.119
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发表时间：
2010-01-14
期刊：
影响因子：
2.9
通讯作者：
Detre, John A.
中科院分区：
文献类型：
--
作者：
Ances, Beau M.;Greenberg, Joel H.;Detre, John A.
用信号平均激光多普勒(LD)流量计研究了一氧化氮(NO)在周期性电刺激前爪的激活-流耦合(AFC)反应中的作用。分别在非选择性一氧化氮合酶抑制剂L精氨酸(40 mg/kg)腹腔注射前和注射后计算脑血流量。应用L-NNA后，可观察到特征性的基线低频血管运动振荡(0.17 Hz)。这些LDCBF振荡在半球内是同步的，但在两个半球之间不是同步的。对于较长的刺激(1分钟)和较长的刺激间隔(2分钟)，L-NNA降低了AFC反应的幅度(p<；0.05)。相反，L-NNA治疗后，对短持续时间刺激(4秒)和短刺激间期(20秒)的AFC反应的幅度增加(p<；0.05)。L-NNA诱发的血管运动振荡与AFC反应之间存在相互作用，最大的增加发生在最接近振荡频率的刺激谐波处。因此，一氧化氮可能会调节参与血管运动振荡和AFC反应的其他血管扩张剂的作用。
The role of nitric oxide (NO) in the activation-flow coupling (AFC) response to periodic electrical forepaw stimulation was investigated using signal averaged laser Doppler (LD) flowmetry. LD measures of calculated cerebral blood flow (CBF) were obtained both prior and after intra-peritoneal administration of the non-selective nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine (L-NNA) (40 mg/kg). Characteristic baseline low frequency vasomotion oscillations (0.17 Hz) were observed after L-NNA administration. These LDCBF oscillations were synchronous within but not between hemispheres. L-NNA reduced the magnitude of the AFC response (p< 0.05) for longer stimuli (1 minute) with longer inter-stimulus intervals (2 minutes). In contrast, the magnitude of the AFC response for short duration stimuli (4 seconds) with short inter-stimulus intervals (20 seconds) was augmented (p < 0.05) after L-NNA. An interaction occurred between L-NNA induced vasomotion oscillations and the AFC response with the greatest increase occurring at the stimulus harmonic closest to the oscillatory frequency. Nitric oxide may therefore modulate the effects of other vasodilators involved in vasomotion oscillations and the AFC response.
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DOI：
10.1152/ajpregu.1996.271.4.r990
发表时间：
1996-10-01
影响因子：
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作者：
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影响因子：
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