Rehospitalization in surviving patients of out-of-hospital ventricular fibrillation (the CASCADE Study). Cardiac Arrest in Seattle: Conventional Amiodarone Drug Evaluation.
Rehospitalization in surviving patients of out-of-hospital ventricular fibrillation (the CASCADE Study). Cardiac Arrest in Seattle: Conventional Amiodarone Drug Evaluation.
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院外室颤幸存患者的再住院（CASCADE 研究）。
DOI：
10.1016/0002-9149(93)90300-2
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Maynard,C
中科院分区：
文献类型：
--
作者：
Maynard,C
院外心室颤动 (VF) 的存活患者在首次出院后通常需要再次住院，但对于再次住院的频率或原因知之甚少。对参加西雅图心脏骤停：传统胺碘酮药物评估 (CASCADE) 研究的 224 名患者进行了再住院检查，该研究是一项随机临床试验，比较胺碘酮与其他抗心律失常药物治疗院外心室颤动幸存者的情况。年再住院率为 79 100 名患者/年； 224 名患者中有 168 名 (75%) 在审查或心脏死亡之前至少住院过一次。再住院患者的基线心室射血分数显着降低。随机接受胺碘酮治疗的患者和使用自动植入式心脏复律除颤器的患者的再住院率较低，但两者差异均无统计学意义。然而，使用自动植入式心律转复除颤器的患者首次再住院的住院时间较短 (p= 0.005)。超过50%的患者在入组后第一年再次住院； 65% 射血分数≤ 0.3 的患者在第一年再次住院。对于院外室颤的幸存患者，特别是射血分数低的患者来说，再住院是很常见的情况。
Surviving patients of out-of-hospital ventricular fibrillation (VF) often need rehospitalization after initial hospital discharge, but little is known regarding the frequency of or reasons for rehospitalization. Rehospitalization was examined in 224 patients enrolled in the Cardiac Arrest in Seattle: Conventional Amiodarone Drug Evaluation (CASCADE) study, a randomized clinical trial comparing amiodarone with other antiarrhythmic drug therapy in survivors of out-of-hospital VF. The annual rate of rehospitalization was 79 100 patients/year; 168 of 224 patients (75%) were hospitalized at least once before censoring or cardiac mortality. Baseline toft ventricular ejection fraction was significantly lower in patients who were rehospitalized. Rehospitalization rates were lower in patients randomized to amiodarone therapy and in those with the automatic implantable cardioverter-defibrillator, although neither difference was statistically significant. However, length of stay for the first rehospitalization was shorter for patients with automatic implantable cardioverterdefibrillators (p= 0.005). More than 50% of patients were rehospitalized in the first year after enrollment; 65% with ejection fractions≤ 0.3 were rehospitalized in the first year. Rehospitalization was a frequent occurrence for surviving patients of out-of-hospital VF, particularly in those with low ejection fractions.
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