High tumor budding stratifies breast cancer with metastatic properties.
High tumor budding stratifies breast cancer with metastatic properties.
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DOI：
10.1007/s10549-015-3333-3
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发表时间：
2015-04
影响因子：
3.8
通讯作者：
Tapia, Coya
中科院分区：
文献类型：
--
作者：
Salhia, Bodour;Trippel, Mafalda;Pfaltz, Katrin;Cihoric, Nikola;Grogg, Andre;Laedrach, Claudia;Zlobec, Inti;Tapia, Coya
肿瘤出芽是指单个或小簇肿瘤细胞从主肿瘤块上脱落。在结肠癌中，高肿瘤出芽与淋巴结阳性和较差的预后相关。因此，我们研究了肿瘤出芽作为乳腺癌（BC）淋巴结状态预测特征的价值。在一张用全细胞角蛋白染色的载玻片上分析了 148 个手术切除标本 (SRS) 和 99 个匹配的术前核心活检 (CB)（无特殊类型的侵袭性 BC）的全组织切片。在SRS中，计算了10个高倍视野（HPF）中瘤内（ITB）和周围肿瘤芽（PTB）的总数。芽被定义为单个肿瘤细胞或最多五个肿瘤细胞的簇。高肿瘤出芽相当于 10HPF 中平均得分 > 4 个肿瘤芽。在 CB 中，高肿瘤出芽定义为≥10 个芽/HPF。结果与病理参数相关。在 SRS 中，高 PTB 分层 BC 伴有淋巴结转移 (p ≤ 0.03) 和淋巴侵犯 (p ≤ 0.015)。在 CB 中，高肿瘤出芽与静脉侵犯显着相关（p = 0.0063）。病理学家能够根据形态学，部分根据淋巴结状态将 BC 分为高风险组和低风险组。这种风险评估可以在常规诊断过程中轻松进行，并且具有时间和成本效益。这些结果表明高 PTB 与局部区域转移相关，强调了这种肿瘤特征可能有助于治疗决策的可能性。
Tumor budding refers to single or small cluster of tumor cells detached from the main tumor mass. In colon cancer high tumor budding is associated with positive lymph nodes and worse prognosis. Therefore, we investigated the value of tumor budding as a predictive feature of lymph node status in breast cancer (BC). Whole tissue sections from 148 surgical resection specimens (SRS) and 99 matched preoperative core biopsies (CB) with invasive BC of no special type were analyzed on one slide stained with pan-cytokeratin. In SRS, the total number of intratumoral (ITB) and peripheral tumor buds (PTB) in ten high-power fields (HPF) were counted. A bud was defined as a single tumor cell or a cluster of up to five tumor cells. High tumor budding equated to scores averaging >4 tumor buds across 10HPFs. In CB high tumor budding was defined as ≥10 buds/HPF. The results were correlated with pathological parameters. In SRS high PTB stratified BC with lymph node metastases (p ≤ 0.03) and lymphatic invasion (p ≤ 0.015). In CB high tumor budding was significantly (p = 0.0063) associated with venous invasion. Pathologists are able, based on morphology, to categorize BC into a high and low risk groups based in part on lymph node status. This risk assessment can be easily performed during routine diagnostics and it is time and cost effective. These results suggest that high PTB is associated with loco-regional metastasis, highlighting the possibility that this tumor feature may help in therapeutic decision-making.
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影响因子：
2.5
作者：
Polyak, K;Hu, M
通讯作者：
Hu, M
影响因子：
--
作者：
Zlobec I;Lugli A
通讯作者：
Lugli A
影响因子：
1.2
作者：
Zlobec, Inti;Suter, Guido;Lugli, Alessandro
通讯作者：
Lugli, Alessandro
片仔癀通过抑制 HIF-1 通路抑制缺氧诱导的人结肠癌细胞上皮间质转化
影响因子：
2.7
作者：
Chen H;Shen A;Zhang Y;Chen Y;Lin J;Lin W;Sferra T;Peng J
通讯作者：
Peng J
影响因子：
158.5
作者：
van de Vijver, MJ;He, YD;Bernards, R
通讯作者：
Bernards, R