Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget.
Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget.
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DOI：
10.18632/oncotarget.199
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Lugli A
中科院分区：
文献类型：
--
作者：
Zlobec I;Lugli A
上皮间质转化(EMT)被认为是上皮细胞获得恶性表型的重要机制。在结直肠癌中，接受EMT的肿瘤细胞在组织学上表现为肿瘤芽的存在，其定义为侵袭前沿的单个细胞或小簇去分化的肿瘤细胞。肿瘤萌发不是一种静态的组织学特征，而是侵袭性肿瘤的动态过程的快照，具有扩散和转移的潜力。有力、一致的证据表明，肿瘤萌芽是淋巴结转移、远处转移疾病、局部复发、总体和无病生存时间较差的预测因素，也是一个独立的预后因素。此外，国际抗癌联合会(UICC)承认肿瘤萌发是一个高度相关的额外预后参数。该综述的目的是总结支持将肿瘤萌发应用于诊断病理学和患者管理的证据，并进一步说明其作为潜在治疗靶点的价值。
Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells. In colorectal cancer, tumor cells having undergone EMT are histologically represented by the presence of tumor buds defined as single cells or small clusters of de-differentiated tumor cells at the invasive front. Tumor budding is not a static, histological feature rather it represents a snap-shot of a dynamic process undertaken by an aggressive tumor with the potential to disseminate and metastasize. Strong, consistent evidence shows that tumor budding is a predictor of lymph node metastasis, distant metastatic disease, local recurrence, worse overall and disease-free survival time and an independent prognostic factor. Moreover, the International Union against Cancer (UICC) recognizes tumor budding as a highly relevant, additional prognostic parameter. The aim of this review is to summarize the evidence supporting the implementation of tumor budding into diagnostic pathology and patient management and additionally to illustrate its worthiness as a potential therapeutic target.
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影响因子：
3.9
作者：
HASE, K;SHATNEY, C;VIERRA, M
通讯作者：
VIERRA, M
影响因子：
8.4
作者：
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影响因子：
2.7
作者：
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通讯作者：
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影响因子：
2.8
作者：
Choi, Hong-Jo;Park, Ki-Jae;Lee, Hyung-Sik
通讯作者：
Lee, Hyung-Sik
DOI：
10.1111/j.1349-7006.2001.tb01062.x
发表时间：
2001-10
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Fujiya M;Watari J;Ashida T;Honda M;Tanabe H;Fujiki T;Saitoh Y;Kohgo Y
通讯作者：
Kohgo Y