Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients.
Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients.
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DOI：
10.1186/1465-9921-10-78
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发表时间：
2009-08-24
影响因子：
5.8
通讯作者：
Hiemstra PS
中科院分区：
文献类型：
--
作者：
Koczulla R;Dragonieri S;Schot R;Bals R;Gauw SA;Vogelmeier C;Rabe KF;Sterk PJ;Hiemstra PS
呼出气冷凝液（EBC）分析是一种非侵入性方法，用于研究炎症性肺病患者气道分泌物的酸度（pH）。评估两种市售器械（便携式RTube和非便携式ECoScreen）在健康对照、哮喘或COPD患者和急性感冒伴下呼吸道症状受试者中的EBC pH重现性。此外，我们评估了健康对照的重复性。使用RTube和ECoScreen从40名受试者（上述每组n = 10）中收集EBC。在5天内，在两个不同的场合从对照中收集EBC。在对照组中，通过RTube或ECoScreen收集的EBC中的pH值测量结果显示，设备之间（p = 0.754）或收集天数之间（重复性系数RTube：0.47; ECoScreen：0.42）无显著差异。两种设备在哮喘、COPD和感冒患者中收集的EBC pH值之间的比较也显示出良好的再现性。在对照组（平均pH 8.27; RTube）和COPD（pH 7.97）或哮喘（pH 8.20）患者之间未观察到pH值差异，但在感冒患者中使用两种器械时发现pH值较低（pH 7.56; RTube，p < 0.01; ECoScreen，p < 0.05）。我们得出结论，通过RTube和ECoScreen收集的EBC中的pH测量值在健康对照中是可重复和可再现的，并且在健康对照、COPD和哮喘患者以及普通感冒受试者中是可重复和可比较的。
Analysis of exhaled breath condensate (EBC) is a non-invasive method for studying the acidity (pH) of airway secretions in patients with inflammatory lung diseases. To assess the reproducibility of EBC pH for two commercially available devices (portable RTube and non-portable ECoScreen) in healthy controls, patients with asthma or COPD, and subjects suffering from an acute cold with lower-airway symptoms. In addition, we assessed the repeatability in healthy controls. EBC was collected from 40 subjects (n = 10 in each of the above groups) using RTube and ECoScreen. EBC was collected from controls on two separate occasions within 5 days. pH in EBC was assessed after degasification with argon for 20 min. In controls, pH-measurements in EBC collected by RTube or ECoScreen showed no significant difference between devices (p = 0.754) or between days (repeatability coefficient RTube: 0.47; ECoScreen: 0.42) of collection. A comparison between EBC pH collected by the two devices in asthma, COPD and cold patients also showed good reproducibility. No differences in pH values were observed between controls (mean pH 8.27; RTube) and patients with COPD (pH 7.97) or asthma (pH 8.20), but lower values were found using both devices in patients with a cold (pH 7.56; RTube, p < 0.01; ECoScreen, p < 0.05). We conclude that pH measurements in EBC collected by RTube and ECoScreen are repeatable and reproducible in healthy controls, and are reproducible and comparable in healthy controls, COPD and asthma patients, and subjects with a common cold.
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影响因子：
15.9
作者：
LEMANSKE, RF;DICK, EC;BUSSE, WW
通讯作者：
BUSSE, WW
影响因子：
2.5
作者：
Petrosyan, Marina;Perraki, Eleni;Gratziou, Christina
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影响因子：
24.3
作者：
Kullmann, T.;Barta, I.;Horvath, I.
通讯作者：
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影响因子：
7.7
作者：
BLAND, JM;ALTMAN, DG
通讯作者：
ALTMAN, DG
DOI：
10.1164/ajrccm.161.3.9911005
发表时间：
2000-03-01
影响因子：
24.7
作者：
Hunt, JF;Fang, KZ;Gaston, B
通讯作者：
Gaston, B