Pathogenesis of HIV and the lung.
Pathogenesis of HIV and the lung.
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DOI：
10.1007/s11904-012-0140-x
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发表时间：
2013-03
影响因子：
4.6
通讯作者：
Morris, Alison
中科院分区：
文献类型：
--
作者：
Gingo, Matthew R.;Morris, Alison
关键词：
抗逆转录病毒治疗延长了艾滋病毒感染者的寿命，但长期艾滋病毒感染现在因包括肺部疾病在内的慢性疾病发病率增加而变得复杂。慢性阻塞性肺病、肺癌、哮喘和肺动脉高压正在成为艾滋病毒感染的常见合并症，这些疾病可能是艾滋病毒相关危险因素的结果，如抗逆转录病毒药物毒性、传染性微生物定植、艾滋病毒病毒血症、免疫激活或免疫功能障碍。控制艾滋病毒感染的能力似乎并不能完全消除细菌性肺炎和结核病等感染性并发症的风险。正在阐明艾滋病毒感染对肺部特异性免疫反应的影响，以帮助为艾滋病毒感染者制定更好的预防和治疗策略。
Antiretroviral therapy has improved longevity for HIV-infected persons, but long-term HIV infection is now complicated by increased rates of chronic medical conditions including pulmonary disorders. Chronic obstructive pulmonary disease, lung cancer, asthma, and pulmonary hypertension are becoming common comorbidities of HIV infection, and these diseases may develop as a result of HIV-related risk factors such as antiretroviral drug toxicities, colonization by infectious organisms, HIV viremia, immune activation, or immune dysfunction. It also appears that the ability to control HIV infection does not completely eliminate the risk for infectious complications such as bacterial pneumonia and tuberculosis. The effect of HIV infection on lung-specific immune responses is being elucidated to help develop better prevention and treatment strategies in HIV-infected persons.
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影响因子：
14.2
作者：
Appleton, SL;Adams, RJ;Ruffin, RE
通讯作者：
Ruffin, RE
DOI：
10.1056/nejmoa1013607
发表时间：
2011-10-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Havlir DV;Kendall MA;Ive P;Kumwenda J;Swindells S;Qasba SS;Luetkemeyer AF;Hogg E;Rooney JF;Wu X;Hosseinipour MC;Lalloo U;Veloso VG;Some FF;Kumarasamy N;Padayatchi N;Santos BR;Reid S;Hakim J;Mohapi L;Mugyenyi P;Sanchez J;Lama JR;Pape JW;Sanchez A;Asmelash A;Moko E;Sawe F;Andersen J;Sanne I;AIDS Clinical Trials Group Study A5221
通讯作者：
AIDS Clinical Trials Group Study A5221
影响因子：
56.9
作者：
COCCHI, F;DEVICO, AL;LUSSO, P
通讯作者：
LUSSO, P
影响因子：
8.8
作者：
Dal Maso, L.;Polesel, J.;Franceschi, S.
通讯作者：
Franceschi, S.
影响因子：
1.5
作者：
George, M. Patricia;Brower, Alexandra;Norris, Karen A.
通讯作者：
Norris, Karen A.