SUICIDAL THOUGHTS AND BEHAVIORS IN CHILDREN AND ADOLESCENTS WITH CHRONIC TIC DISORDERS.
SUICIDAL THOUGHTS AND BEHAVIORS IN CHILDREN AND ADOLESCENTS WITH CHRONIC TIC DISORDERS.
复制标题
患有慢性抽动障碍的儿童和青少年的自杀想法和行为。
DOI：
10.1002/da.22357
复制
发表时间：
2015
影响因子：
7.4
通讯作者：
Murphy,TanyaK
中科院分区：
文献类型：
--
作者：
Storch,EricA;Hanks,CamilleE;Mink,JonathanW;McGuire,JosephF;Adams,HeatherR;Augustine,ErikaF;Vierhile,Amy;Thatcher,Alyssa;Bitsko,Rebecca;Lewin,AdamB;Murphy,TanyaK
尽管有证据表明，患有抽动症和慢性抽动障碍(CTD)的青少年自杀念头和自杀行为的危险因素增加，但很少有研究真正检验这种关系。这项研究记录了患有CTD的儿童和青少年(N=196，6-18岁)自杀念头和行为的频率和临床相关性。内容完全由作者负责，不一定代表疾病控制中心的官方观点。方法青少年和父母完成了一系列测量，以评估共生的精神诊断、儿童情绪和行为症状以及因抽搐或共生条件造成的损害。结果一项结构化的诊断性访谈发现，19名患有CTD的青少年(9.7%)有过自杀念头和/或行为，高于社区对照样本中有过这些想法的3名年轻人(3%)(N=100，6-18岁，P=.03)。对于患有CTD的青少年来说，自杀的想法和行为经常在愤怒和沮丧的背景下得到认可。儿童行为量表(CBCL)的焦虑/抑郁、孤僻、社交问题、思维问题和攻击行为子量表以及总的内化问题量表与自杀念头和/或行为的存在有关。自杀念头和/或行为与抽动症状严重程度、抽动相关损害以及强迫症、抑郁、焦虑和注意缺陷/多动障碍的症状严重程度显著相关。CBCL焦虑/抑郁评分在抽动严重程度与自杀念头和自杀行为之间起中介作用。结论约十分之一的CTD青少年有过自杀念头和/或行为，自杀念头和/或行为与较复杂的临床表现有关，且常发生在愤怒和沮丧的情况下。
ObjectiveDespite evidence of elevated risk factors for suicidal thoughts and behavior in youth with Tourette syndrome and chronic tic disorders (CTD), few studies have actually examined that relationship. This study documented the frequency and clinical correlates of suicidal thoughts and behaviors in a sample of children and adolescents with CTD (N= 196, range 6–18 years old). The content is solely the responsibility of the authors and does not necessarily represent the official views of the Centers for Disease Control.MethodYouth and parents completed a battery of measures that assessed co‐occurring psychiatric diagnoses, child emotional and behavioral symptoms, and impairment due to tics or co‐occurring conditions.ResultsA structured diagnostic interview identified that 19 youths with CTD (9.7%) experienced suicidal thoughts and/or behaviors, which was elevated compared to 3 youths (3%) who experienced these thoughts in a community control sample (N= 100, range 6–18 years old,P= .03). For youth with CTD, suicidal thoughts and behaviors were frequently endorsed in the context of anger and frustration. The Child Behavior Checklist (CBCL) anxious/depressed, withdrawn, social problems, thought problems, and aggressive behavior subscales, as well as the total internalizing problems scale, were associated with the presence of suicidal thoughts and/or behaviors. Suicidal thoughts and/or behaviors were significantly associated with tic symptom severity; tic‐related impairment; and obsessive–compulsive, depressive, anxiety, and attention‐deficit/hyperactivity disorders’ symptom severity. CBCL anxiety/depression scores mediated the relationship between tic severity and suicidal thoughts and behaviors.ConclusionsFindings suggest that about 1 in 10 youth with CTD experience suicidal thoughts and/or behaviors, which are associated with a more complex clinical presentation and often occur in the presence of anger and frustration.
登录
查看更多内容
由人类吞噬细胞引起的突变。
影响因子：
56.9
作者：
S. Weitzman;T. Stossel
通讯作者：
T. Stossel
测量人类中性粒细胞产生的 O2-。
影响因子：
--
作者：
M. Markert;P. Andrews;B. Babior
通讯作者：
B. Babior
细菌吞噬作用诱导的突变。
DOI：
--
发表时间：
1983
期刊：
Mutation research
影响因子：
--
作者：
M. Barak;Shimon Ulitzur;D. Merzbach
通讯作者：
D. Merzbach
受刺激的人类吞噬细胞在培养的哺乳动物细胞中产生细胞遗传学变化。
DOI：
10.1056/nejm198301063080107
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
Alan B. Weitberg;Sigmund A. Weitzman;Margaret Destrempes;Samuel A. Latt;T. Stossel
通讯作者：
T. Stossel
人吞噬细胞对 DNA-抗 DNA 复合物的吞噬和降解 I. 人血单核细胞和中性粒细胞的测定条件、定量方面以及差异
影响因子：
5.4
作者：
M. Lamers;Elisabeth R. de Groot;D. Roos
通讯作者：
D. Roos