Moving Toward Understanding Autism: Visual-Motor Integration, Imitation, and Social Skill Development.
Moving Toward Understanding Autism: Visual-Motor Integration, Imitation, and Social Skill Development.
复制标题
走向理解自闭症：视觉运动整合，模仿和社会技能发展。
DOI：
10.1016/j.pediatrneurol.2021.06.010
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发表时间：
2021-09
影响因子：
3.8
通讯作者：
Mostofsky SH
中科院分区：
文献类型：
--
作者：
Lidstone DE;Mostofsky SH
自闭症谱系障碍（ASD）是一种神经发育障碍，其行为表型以社交技能发展受损以及过度重复和刻板行为为特征。尽管ASD的表型异质性很高，但ASD儿童的一个重要亚群（约90%）表现出明显的一般运动障碍。对ASD运动障碍本质的更集中的研究表明，ASD儿童在诸如接球和运动模仿等需要有效视觉-运动整合（VMI）的任务上尤其受损。运动计算方法也为vmi损伤提供了证据，表明ASD儿童形成的内部感觉运动表征偏向于本体感觉而不是视觉反馈。视觉信息整合能力受损，无法形成对他人和外部世界的内部表征，这可以解释观察到的vmi任务和他人运动模仿障碍。运动模仿对于获得社交技能和运动技能至关重要，模仿技能受损可能是观察到的ASD核心行为表型的原因之一。目前的综述研究了支持vmi损伤作为ASD核心特征的证据，它可能导致运动模仿和社交技能发展受损。我们认为，了解ASD中vmi损伤的神经生物学机制可能是发现治疗儿童和成人ASD残疾的关键。
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a behavioral phenotype characterized by impaired development of social-communicative skills as well as excessive repetitive and stereotyped behaviors. Despite high phenotypic heterogeneity in ASD, a meaningful subpopulation of children with ASD (~90%) show significant general motor impairment.. More focused studies on the nature of motor impairment in ASD reveal that children with ASD are particularly impaired on tasks such as ball catching and motor imitation that require efficient visual-motor integration (VMI). Motor computational approaches also provide evidence for VMI-impairment showing that children with ASD form internal sensorimotor representations that bias proprioceptive over visual-feedback. Impaired integration of visual information to form internal representations of others’ and the external world may explain observed impairments on VMI-tasks and motor imitation of others. Motor imitation is crucial for acquiring both social and motor skills and impaired imitation skill may contribute to the observed core behavioral phenotype of ASD. The current review examines evidence supporting VMI-impairment as a core feature of ASD that may contribute to both impaired motor imitation and social-communicative skill development. We propose that understanding the neurobiological mechanisms underlying VMI-impairment in ASD may be key to discovery of therapeutics to address disability in children and adults with ASD.
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影响因子：
2
作者：
Blakemore, SJ;Sirigu, A
通讯作者：
Sirigu, A
影响因子：
25
作者：
Haswell, Courtney C.;Izawa, Jun;Dowell, Lauren R.;Mostofsky, Stewart H.;Shadmehr, Reza
通讯作者：
Shadmehr, Reza
影响因子：
4.2
作者：
DMello, Anila M.;Crocetti, Deana;Mostofsky, Stewart H.;Stoodley, Catherine J.
通讯作者：
Stoodley, Catherine J.
DOI：
10.15585/mmwr.ss6706a1
发表时间：
2018-04-27
期刊：
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
影响因子：
--
作者：
Baio J;Wiggins L;Christensen DL;Maenner MJ;Daniels J;Warren Z;Kurzius-Spencer M;Zahorodny W;Robinson Rosenberg C;White T;Durkin MS;Imm P;Nikolaou L;Yeargin-Allsopp M;Lee LC;Harrington R;Lopez M;Fitzgerald RT;Hewitt A;Pettygrove S;Constantino JN;Vehorn A;Shenouda J;Hall-Lande J;Van Naarden Braun K;Dowling NF
通讯作者：
Dowling NF
DOI：
10.1007/bf01537618
发表时间：
1972-01-01
期刊：
JOURNAL OF AUTISM AND CHILDHOOD SCHIZOPHRENIA
影响因子：
--
作者：
DEMYER, MK;ALPERN, GD;KIMBERLI.C
通讯作者：
KIMBERLI.C