Representation of internal models of action in the autistic brain.

Representation of internal models of action in the autistic brain.
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DOI:
10.1038/nn.2356
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发表时间:
2009-08
影响因子:
25
通讯作者:
Shadmehr, Reza
Shadmehr, Reza
中科院分区:
医学1区
文献类型:
--
作者:
Haswell, Courtney C.;Izawa, Jun;Dowell, Lauren R.;Mostofsky, Stewart H.;Shadmehr, Reza

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患有自闭症谱系障碍 (ASD) 的儿童在运动控制、模仿和社交功能方面表现出缺陷。代表内部行动模型的神经基础功能障碍是否会导致这些问题?我们测量了儿童学习控制新工具时的泛化模式,发现自闭症患者的大脑在自我生成的运动命令和本体感觉反馈之间建立了比正常更强的关联;此外,对本体感觉的依赖越大,孩子的社会功能和模仿能力的障碍就越大。
Children with autism spectrum disorder (ASD) exhibit deficits in motor control, imitation, and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child’s impairments in social function and imitation.
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