Representation of internal models of action in the autistic brain.
Representation of internal models of action in the autistic brain.
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DOI:
10.1038/nn.2356
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发表时间:
2009-08
影响因子:
25
通讯作者:
Shadmehr, Reza
中科院分区:
文献类型:
--
作者:
Haswell, Courtney C.;Izawa, Jun;Dowell, Lauren R.;Mostofsky, Stewart H.;Shadmehr, Reza
Children with autism spectrum disorder (ASD) exhibit deficits in motor control, imitation, and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child’s impairments in social function and imitation.
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