Emerging role of lipid metabolism alterations in Cancer stem cells.
Emerging role of lipid metabolism alterations in Cancer stem cells.
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脂质代谢改变在癌症干细胞中的新作用
DOI：
10.1186/s13046-018-0784-5
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发表时间：
2018-06-15
期刊：
影响因子：
--
通讯作者：
Xiang B
中科院分区：
文献类型：
--
作者：
Yi M;Li J;Chen S;Cai J;Ban Y;Peng Q;Zhou Y;Zeng Z;Peng S;Li X;Xiong W;Li G;Xiang B
背景肿瘤干细胞（cancer stem cells，CSC）或肿瘤起始细胞（tumor-initiating cells，TIC）是一类具有自我更新和肿瘤起始特性的肿瘤细胞。与大部分肿瘤细胞不同，CSC或TIC对传统疗法是难治的，并且是癌症患者中复发或疾病复发的原因。干细胞有不同的代谢特性相比，分化的细胞，和代谢重新布线有助于自我更新和sterness维护CSCs.Main body代谢组学检测，特别是在高光谱刺激拉曼散射显微镜的最新进展，扩大了我们的知识的贡献脂质代谢的生成和维护的CSCs。脂质摄取、从头脂肪生成、脂滴、脂质去饱和和脂肪酸氧化的改变都清楚地涉及CSC调节。脂质代谢的改变不仅可以满足CSC的能量需求和生物量生产，而且还有助于激活几个重要的致癌信号通路，包括Wnt/β-catenin和Hippo/雅普信号通路。在这篇综述中，我们总结了目前的进展，在这一有吸引力的领域，并描述了一些最近的治疗药物，专门针对CSCs的基础上，他们的调制脂质代谢。靶向脂肪酸代谢的关键参与者显示出抗CSC和肿瘤预防效果的前景。
BackgroundCancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs.Main bodyRecent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs. Alterations in lipid uptake, de novo lipogenesis, lipid droplets, lipid desaturation, and fatty acid oxidation are all clearly implicated in CSCs regulation. Alterations on lipid metabolism not only satisfies the energy demands and biomass production of CSCs, but also contributes to the activation of several important oncogenic signaling pathways, including Wnt/β-catenin and Hippo/YAP signaling. In this review, we summarize the current progress in this attractive field and describe some recent therapeutic agents specifically targeting CSCs based on their modulation of lipid metabolism.ConclusionIncreased reliance on lipid metabolism makes it a promising therapeutic strategy to eliminate CSCs. Targeting key players of fatty acids metabolism shows promising to anti-CSCs and tumor prevention effects.
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DOI：
10.1080/15384101.2016.1220456
发表时间：
2016-10-17
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Bengoechea-Alonso MT;Ericsson J
通讯作者：
Ericsson J
影响因子：
1.4
作者：
Alptekin A;Ye B;Ding HF
通讯作者：
Ding HF
影响因子：
3.8
作者：
Belkaid A;Duguay SR;Ouellette RJ;Surette ME
通讯作者：
Surette ME
影响因子：
4.7
作者：
Baillie R;Tan ST;Itinteang T
通讯作者：
Itinteang T
Nanog通过氧化磷酸化和脂肪酸代谢的肿瘤性变化来代谢重新编程肿瘤发射类样细胞。
影响因子：
29
作者：
Chen CL;Uthaya Kumar DB;Punj V;Xu J;Sher L;Tahara SM;Hess S;Machida K
通讯作者：
Machida K