Serum Cotinine and Adverse Cardiovascular Outcomes: A Cross-sectional Secondary Analysis of the nuMoM2b Heart Health Study.
Serum Cotinine and Adverse Cardiovascular Outcomes: A Cross-sectional Secondary Analysis of the nuMoM2b Heart Health Study.
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DOI：
10.1055/a-1580-3155
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发表时间：
2023-09
影响因子：
2
通讯作者：
NHLBI nuMoM2b Heart Health Study Network
中科院分区：
文献类型：
--
作者：
Theilen LH;McNeil RB;Hunter S;Grobman WA;Parker CB;Catov JM;Pemberton VL;Ehrenthal DB;Haas DM;Hoffman MK;Chung JH;Mukhtar F;Arzumanyan Z;Mercer B;Parry S;Saade GR;Simhan HN;Wapner RJ;Silver RM;NHLBI nuMoM2b Heart Health Study Network
我们的目的是(1)比较血清可替宁与自我报告来确定育龄妇女的吸烟状况；(2)通过吸烟状况估计女性不良心血管（CV）结局的相对几率；(3)评估不良妊娠结局（APOs）与CV结局之间的关系是否因吸烟状况而异。我们对nuMoM2b心脏健康研究进行了横断面研究。妇女在第一次怀孕后2至7年参加了一次研究访问。暴露是吸烟状况，由自我报告和血清可替宁确定。结果包括慢性高血压（HTN）、代谢综合征（MetS）和血脂异常。多变量logistic回归估计吸烟状况对每个结果的优势比（or）。在检测血清可替宁的4,392名女性中，3,610名被归类为不吸烟者，62名被归类为二手烟暴露者，720名被归类为吸烟者。在3144名否认吸烟的女性中，48名（1.5%）的血清可替宁与二手烟暴露一致，131名（4.2%）的血清可替宁与apo校正后，血清可替宁定义的吸烟与MetS（校正OR [aOR]=1.52, 95%可信区间[CI]: 1.21, 1.91）和血脂异常（aOR=1.28, 95% CI: 1.01, 1.62）相关。当按尼古丁暴露分层时，与没有APO的妇女相比，在其指数妊娠中有APO的非吸烟者有更高的1期（aOR=1.64, 95% CI: 1.32, 2.03）和2期HTN （aOR=2.92, 95% CI: 2.17, 3.93）、MetS （aOR=1.76, 95% CI: 1.42, 2.18）和脂质异常（aOR=1.55, 95% CI: 1.25, 1.91）的几率。当吸烟暴露由自我报告定义时，结果相似。无论是通过血清可替宁测定还是自我报告，在育龄妇女中吸烟与随后的CV结果相关。apo也与女性的CV结果独立相关。
We aimed to (1) compare serum cotinine with self-report for ascertaining smoking status among reproductive-aged women; (2) estimate the relative odds of adverse cardiovascular (CV) outcomes among women by smoking status; (3) assess whether the association between adverse pregnancy outcomes (APOs) and CV outcomes varies by smoking status. We conducted a cross-sectional study of the nuMoM2b Heart Health Study. Women attended a study visit 2 to 7 years after their first pregnancy. The exposure was smoking status, determined by self-report and by serum cotinine. Outcomes included incident chronic hypertension (HTN), metabolic syndrome (MetS), and dyslipidemia. Multivariable logistic regression estimated odds ratios (ORs) for each outcome by smoking status. Of 4,392 women with serum cotinine measured, 3,610 were categorized as nonsmokers, 62 as secondhand smoke exposure, and 720 as smokers. Of 3,144 women who denied tobacco smoke exposure, serum cotinine was consistent with secondhand smoke exposure in 48 (1.5%) and current smoking in 131 (4.2%) After adjustment for APOs, smoking defined by serum cotinine was associated with MetS (adjusted OR [aOR]=1.52, 95% confidence interval [CI]: 1.21, 1.91) and dyslipidemia (aOR=1.28, 95% CI: 1.01, 1.62). When stratified by nicotine exposure, nonsmokers with an APO in their index pregnancy had higher odds of stage 1 (aOR=1.64, 95% CI: 1.32, 2.03) and stage 2 HTN (aOR=2.92, 95% CI: 2.17, 3.93), MetS (aOR=1.76, 95% CI: 1.42, 2.18), and dyslipidemia (aOR=1.55, 95% CI: 1.25, 1.91) relative to women with no APO. Results were similar when smoking exposure was defined by self-report. Whether determined by serum cotinine or self-report, smoking is associated with subsequent CV outcomes in reproductive-aged women. APOs are also independently associated with CV outcomes in women.
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影响因子：
9.8
作者：
Haas, David M.;Parker, Corette B.;Wing, Deborah A.;Parry, Samuel;Grobman, William A.;Mercer, Brian M.;Simhan, Hyagriv N.;Hoffman, Matthew K.;Silver, Robert M.;Wadhwa, Pathik;Iams, Jay D.;Koch, Matthew A.;Caritis, Steve N.;Wapner, Ronald J.;Esplin, Sean;Elovitz, Michal A.;Foroud, Tatiana;Peaceman, Alan M.;Saade, George R.;Willinger, Marian;Reddy, Uma M.
通讯作者：
Reddy, Uma M.
影响因子：
6.7
作者：
BENOWITZ, NL;JACOB, P
通讯作者：
JACOB, P
影响因子：
3.5
作者：
Canoy, Dexter;Cairns, Benjamin J.;Reeves, Gillian
通讯作者：
Reeves, Gillian
DOI：
10.1097/ede.0b013e3182873a73
发表时间：
2013-05
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Engel SM;Scher E;Wallenstein S;Savitz DA;Alsaker ER;Trogstad L;Magnus P
通讯作者：
Magnus P
影响因子：
3.5
作者：
Gastrich, Mary Downes;Zinonos, Stavros;Kostis, John B.
通讯作者：
Kostis, John B.