Radiochemistry for positron emission tomography.
Radiochemistry for positron emission tomography.
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正电子发射断层扫描的放射化学
DOI：
10.1038/s41467-023-36377-4
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发表时间：
2023-06-05
影响因子：
16.6
通讯作者：
Liang, Steven H.
中科院分区：
文献类型：
--
作者：
Rong, Jian;Haider, Ahmed;Jeppesen, Troels E.;Josephson, Lee;Liang, Steven H.
Positron emission tomography (PET) constitutes a functional imaging technique that is harnessed to probe biological processes in vivo. PET imaging has been used to diagnose and monitor the progression of diseases, as well as to facilitate drug development efforts at both preclinical and clinical stages. The wide applications and rapid development of PET have ultimately led to an increasing demand for new methods in radiochemistry, with the aim to expand the scope of synthons amenable for radiolabeling. In this work, we provide an overview of commonly used chemical transformations for the syntheses of PET tracers in all aspects of radiochemistry, thereby highlighting recent breakthrough discoveries and contemporary challenges in the field. We discuss the use of biologicals for PET imaging and highlight general examples of successful probe discoveries for molecular imaging with PET – with a particular focus on translational and scalable radiochemistry concepts that have been entered to clinical use. Positron emission tomography is widely used to diagnose and monitor different disease states and interest in the technique has led to the demand for the development of new method for radiolabelling. Here the authors review the recent progress in the development of new PET probes.
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影响因子：
12.4
作者：
Chakravarty R;Goel S;Cai W
通讯作者：
Cai W
影响因子：
15
作者：
Blackman, Melissa L.;Royzen, Maksim;Fox, Joseph M.
通讯作者：
Fox, Joseph M.
影响因子：
4.9
作者：
Bongarzone, S.;Runser, A.;Gee, A. D.
通讯作者：
Gee, A. D.
影响因子：
8.4
作者：
Benedetto, Elena;Tredwell, Matthew;Gouverneur, Veronique
通讯作者：
Gouverneur, Veronique
DOI：
10.2967/jnumed.120.260455
发表时间：
2021-03
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Carlucci G;Ippisch R;Slavik R;Mishoe A;Blecha J;Zhu S
通讯作者：
Zhu S