A miR-182 variant and risk of hepatocellular carcinoma in a southern Chinese population.
A miR-182 variant and risk of hepatocellular carcinoma in a southern Chinese population.
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中国南方人群的 miR-182 变异与肝细胞癌风险
DOI：
10.1186/s40246-020-00289-x
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发表时间：
2020-10-15
期刊：
影响因子：
4.5
通讯作者：
Yu H
中科院分区：
文献类型：
--
作者：
Qiu M;Liu Y;Lin Q;Zhou Z;Jiang Y;Huo R;Liang X;Yu X;Cao J;Zhou X;Yu H
microRNAs（miRNAs）在转录后水平对基因表达起重要调控作用，参与人类肿瘤的发生。本研究的目的是探讨中国南方人群中miR-182单核苷酸多态性与HCC风险之间的关系。在863例HCC患者和908例无癌对照的病例对照研究中，我们对miR-182 rs 4541843进行了基因分型，并评估了其与HCC风险的相关性。我们发现，与携带GG基因型的个体相比，携带miR-182 rs 4541843 AG/AA基因型的个体与HCC风险增加显著相关（校正比值比（OR）= 1.71，95%置信区间（CI）= 1.07-2.76，P = 0.026）。在分层分析中，这种增加的风险在老年人的亚组中更为明显（校正OR = 1.98，95% CI = 1.04-3.76，P = 0.037），男性（校正OR = 1.81，95% CI = 1.09-2.99，P = 0.021），从不饮酒者（校正OR = 1.84，95% CI = 1.03-3.30，P = 0.041）。提示miR-182基因多态性rs 4541843可能与肝癌易感性有关。我们的发现需要在更大样本量的进一步研究中进行验证。
MicroRNAs (miRNAs) play important roles in the regulation of gene expression at the posttranscriptional level and are involved in human carcinogenesis. The aim of the current study was to investigate the associations between miR-182 single nucleotide polymorphisms and HCC risk in a southern Chinese population. In this case-control study of 863 HCC patients and 908 cancer-free controls, we performed genotyping of miR-182 rs4541843 and assessed its association with HCC risk. We found that individuals carrying the AG/AA genotypes of miR-182 rs4541843 were significantly associated with an increased risk of HCC compared with those carrying the GG genotype (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.07–2.76, P = 0.026). In the stratified analysis, this increased risk was more pronounced in the subgroups of older individuals (adjusted OR = 1.98, 95% CI = 1.04–3.76, P = 0.037), males (adjusted OR = 1.81, 95% CI = 1.09–2.99, P = 0.021), and never drinkers (adjusted OR = 1.84, 95% CI = 1.03–3.30, P = 0.041). Our results suggested that miR-182 polymorphism rs4541843 may contribute to the susceptibility to HCC. Our findings require validation in further studies with larger sample sizes.
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miR-199a rs74723057和MET rs1621多态性与肝细胞癌风险的关联
影响因子：
--
作者：
Wang Q;Yu X;Li Q;Qin L;Tan S;Zeng X;Qiu X;Tang B;Jin J;Liao W;Qiu M;Tan L;He G;Li X;He S;Yu H
通讯作者：
Yu H
影响因子：
3.7
作者：
An J;Liu J;Liu L;Liu Y;Pan Y;Huang M;Qi F;Wen J;Xie K;Ma H;Shen H;Hu Z
通讯作者：
Hu Z
DOI：
10.1073/pnas.0808263106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Segura, Miguel F.;Hanniford, Douglas;Hernando, Eva
通讯作者：
Hernando, Eva
影响因子：
3.5
作者：
Qin, Jun;Luo, Meng;Chen, Wei
通讯作者：
Chen, Wei
MicroRNA-182 下调转移抑制因子 1，促进肝细胞癌的转移。
影响因子：
3.8
作者：
Wang J;Li J;Shen J;Wang C;Yang L;Zhang X
通讯作者：
Zhang X