A genetic variant in primary miR-378 is associated with risk and prognosis of hepatocellular carcinoma in a Chinese population.
A genetic variant in primary miR-378 is associated with risk and prognosis of hepatocellular carcinoma in a Chinese population.
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DOI：
10.1371/journal.pone.0093707
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hu Z
中科院分区：
文献类型：
--
作者：
An J;Liu J;Liu L;Liu Y;Pan Y;Huang M;Qi F;Wen J;Xie K;Ma H;Shen H;Hu Z
已有研究表明，miR-378与细胞存活、肿瘤生长和血管生成有关，并可能参与肝细胞癌的发生和预后。原发miR-378(pri-miR-378)基因变异可能影响miR-378的表达，进而影响肝癌的风险和生存。本研究旨在评估原发miR-378基因变异与肝细胞癌易感性和预后的关系。我们进行了一项病例对照研究，分析了1300例乙肝病毒阳性的肝细胞癌患者和1344例乙肝病毒携带者中pri-miR-378基因rs1076064与肝细胞癌风险的关系。然后，我们评估了331例未经手术治疗的中晚期肝癌患者的基因多态性与肝细胞癌预后的相关性。Rs1076064基因变异与乙肝病毒携带者肝癌风险降低相关[调整优势比(OR) = 为0.90，95%可信区间(CI) = 为0.81~1.00，P = 为0.047]。此外，具有变异基因的肝癌患者具有更好的生存[在加性遗传模型中，调整危险比(HR) = 为0.70，95%顺式 = 为0.59-0.83，P<；0.0001]。报告基因分析表明，rs1076064的G等位基因启动子活性高于A等位基因。这些结果表明，rs1076064可能通过改变pri-miR-378转录而成为预测肝癌易感性和预后的生物标志物。
MiR-378 has been reported to be related to cell survival, tumor growth and angiogenesis and may participate in hepatocellular carcinoma (HCC) development and prognosis. Genetic variants in primary miR-378 (pri-miR-378) may impact miR-378 expression and contribute to HCC risk and survival. This study aimed to assess the associations between a genetic variant in primary miR-378 and HCC susceptibility and prognosis. We conducted a case-control study to analyze the association of rs1076064 in pri-miR-378 with hepatocellular carcinoma risk in 1300 HCC patients with positive hepatitis B virus (HBV) and 1344 HBV carriers. Then, we evaluated the correlation between the polymorphism and hepatocellular carcinoma prognosis in 331 HCC patients at either intermediate or advanced stage without surgical treatment. The variant genotypes of rs1076064 were associated with a decreased HCC risk in HBV carriers [Adjusted odds ratio (OR) = 0.90, 95% confidence intervals (CI) = 0.81–1.00, P = 0.047]. Moreover, HCC patients with the variant genotypes were associated with a better survival [Adjusted hazard ratio (HR) = 0.70, 95% CIs = 0.59–0.83, P<0.0001 in an additive genetic model]. The reporter gene assay showed that the variant G allele of rs1076064 exerted higher promoter activity than the A allele. These findings indicate that rs1076064 may be a biomarker for HCC susceptibility and prognosis through altering pri-miR-378 transcription.
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DOI：
10.1111/j.1440-1746.2008.05666.x
发表时间：
2009-04-01
影响因子：
4.1
作者：
Guo, Junming;Miao, Ying;Wang, Yanjun
通讯作者：
Wang, Yanjun
DOI：
10.4321/s1130-01082012000600003
发表时间：
2012-06-01
期刊：
Revista Española de Enfermedades Digestivas
影响因子：
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作者：
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通讯作者：
Sánchez-Ruano, Juan José
人类白细胞抗原/DP-DQ 的遗传变异影响乙型肝炎病毒清除和肝细胞癌的发展
影响因子：
13.5
作者：
Hu, Lingmin;Zhai, Xiangjun;Hu, Zhibin
通讯作者：
Hu, Zhibin
DOI：
10.1073/pnas.0706901104
发表时间：
2007-12-18
影响因子：
11.1
作者：
Lee, Daniel Y.;Deng, Zhaoqun;Yang, Burton B.
通讯作者：
Yang, Burton B.
影响因子：
56.9
作者：
MAKELA, TP;KOSKINEN, PJ;ALITALO, K
通讯作者：
ALITALO, K