National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the United Kingdom.
National priority setting partnership using a Delphi consensus process to develop neonatal research questions suitable for practice-changing randomised trials in the United Kingdom.
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DOI：
10.1136/bmjopen-2022-061330
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发表时间：
2022-09-28
期刊：
影响因子：
2.9
通讯作者：
Gale, Chris
中科院分区：
文献类型：
--
作者：
Evans, Katie;Battersby, Cheryl;Boardman, James P.;Boyle, Elaine M.;Carroll, William D.;Dinwiddy, Kate;Dorling, Jon;Gallagher, Katie;Hardy, Pollyanna;Johnston, Emma;Mactier, Helen;Marcroft, Claire;Webbe, James;Gale, Chris
需要在方法上进行强有力的临床试验，以改善新生儿护理并减少实践中不必要的差异。以前的新生儿研究优先程序确定了重要的研究主题，而不是适合临床试验的具体研究问题。改变实践的试验需要定义明确的研究问题，通常使用人口、干预、比较、结果(PICO)结构来组织。通过将研究优先事项的范围缩小到那些可以在临床试验中得到回答的研究优先事项，并通过让广泛的不同利益攸关方参与进来，我们的目标是提供一个稳健和透明的过程，以确定和优先处理在国家医疗保健系统内可以回答的研究问题，以告知未来改变实践的临床试验。一个由家长、医生、护士、专职卫生专业人员、研究人员和来自主要组织(新生儿协会、英国围产期医学协会、新生儿护士协会和皇家儿科和儿童健康学院)的代表组成的指导小组被确定为监督该项目。我们将邀请以下利益相关者群体使用在线问卷提交使用PICO结构格式的研究问题：父母、患者、医疗保健专业人员和学术研究人员。未回答的、非重复的研究问题将进入对所有利益相关者群体的三轮eDelphi调查。研究问题将根据平均总分进行排名。优先研究问题的最终清单将通过传统的学术渠道传播，通过代表性组织和社交媒体直接传播给关键的利益相关者群体。该项目的成果将与国家卫生研究所等关键研究机构分享。研究伦理委员会不需要批准。
Methodologically robust clinical trials are required to improve neonatal care and reduce unwanted variations in practice. Previous neonatal research prioritisation processes have identified important research themes rather than specific research questions amenable to clinical trials. Practice-changing trials require well-defined research questions, commonly organised using the Population, Intervention, Comparison, Outcome (PICO) structure. By narrowing the scope of research priorities to those which can be answered in clinical trials and by involving a wide range of different stakeholders, we aim to provide a robust and transparent process to identify and prioritise research questions answerable within the National Healthcare System to inform future practice-changing clinical trials. A steering group comprising parents, doctors, nurses, allied health professionals, researchers and representatives from key organisations (Neonatal Society, British Association of Perinatal Medicine, Neonatal Nurses Association and Royal College of Paediatrics and Child Health) was identified to oversee this project. We will invite submissions of research questions formatted using the PICO structure from the following stakeholder groups using an online questionnaire: parents, patients, healthcare professionals and academic researchers. Unanswered, non-duplicate research questions will be entered into a three-round eDelphi survey of all stakeholder groups. Research questions will be ranked by mean aggregate scores. The final list of prioritised research questions will be disseminated through traditional academic channels, directly to key stakeholder groups through representative organisations and on social media. The outcome of the project will be shared with key research organisations such as the National Institute for Health Research. Research ethics committee approval is not required.
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DOI：
10.1056/nejmoa2022926
发表时间：
2020-11-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
RECOVERY Collaborative Group;Horby P;Mafham M;Linsell L;Bell JL;Staplin N;Emberson JR;Wiselka M;Ustianowski A;Elmahi E;Prudon B;Whitehouse T;Felton T;Williams J;Faccenda J;Underwood J;Baillie JK;Chappell LC;Faust SN;Jaki T;Jeffery K;Lim WS;Montgomery A;Rowan K;Tarning J;Watson JA;White NJ;Juszczak E;Haynes R;Landray MJ
通讯作者：
Landray MJ
影响因子：
2.9
作者：
Ho, Alison;Webster, Louise;Chappell, Lucy
通讯作者：
Chappell, Lucy
影响因子：
2.9
作者：
Pierrat, Veronique;Burguet, Antoine;Kaminski, Monique
通讯作者：
Kaminski, Monique
影响因子：
3.6
作者：
Johnson, Mark J.;Lapillonne, Alexandre;Bronsky, Jiri;Domellof, Magnus;Embleton, Nicholas;Iacobelli, Silvia;Jochum, Frank;Joosten, Koen;Kolacek, Sanja;Mihatsch, Walter A.;Moltu, Sissel J.;Puntis, John W. L.;Riskin, Arieh;Shamir, Raanan;Tabbers, Merit M.;Van Goudoever, Johannes B.;Saenz de Pipaon, Miguel
通讯作者：
Saenz de Pipaon, Miguel
DOI：
10.1136/bmj.e7961
发表时间：
2012-12-04
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moore T;Hennessy EM;Myles J;Johnson SJ;Draper ES;Costeloe KL;Marlow N
通讯作者：
Marlow N