Drusen regression is associated with local changes in fundus autofluorescence in intermediate age-related macular degeneration.
Drusen regression is associated with local changes in fundus autofluorescence in intermediate age-related macular degeneration.
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DOI：
10.1016/j.ajo.2013.04.031
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发表时间：
2013-09
影响因子：
4.2
通讯作者：
Wong, Wai T.
中科院分区：
文献类型：
--
作者：
Toy, Brian C.;Krishnadev, Nupura;Indaram, Maanasa;Cunningham, Denise;Cukras, Catherine A.;Chew, Emily Y.;Wong, Wai T.
目的探讨中度年龄相关性黄斑变性（AMD）患者玻璃膜疣消退与眼底照相和眼底自发荧光（FAF）成像改变的关系。前瞻性观察病例系列。在2年内，对58例（58例患者）患有中度AMD和大玻璃疣的眼底图像进行评估，以确定玻璃疣消退面积是否超过C1圈（直径125μm; AMD相关眼病研究分级方案）的面积。手动分割和基于计算机的图像分析用于检测和描绘玻璃疣消退的区域。根据眼底照片和FAF图像上的外观对描绘的区域进行分级，并手动对FAF信号的变化进行分级，并使用自动图像分析进行定量。使用手动（48%）和计算机辅助（50%）技术在大约一半的研究眼中检测到玻璃疣消退。在第2年，眼底照相中玻璃疣消退区域的临床表现大多不明显，大多数眼睛（71%）未显示可检测的临床异常，其余眼睛（29%）显示轻微的色素改变。然而，玻璃疣消退区域与FAF的局部变化相关，FAF的局部变化比眼底照相的变化显著更显著。大多数眼睛（64-66%）表现出总体FAF信号的显著降低，而14-21%的眼睛表现出总体FAF信号的显著增加。FAF成像显示，中期AMD的玻璃疣消退往往伴随着局部自发荧光信号的变化。玻璃疣消退可能与外层视网膜的并发结构和生理变化有关。
To investigate the association of spontaneous drusen regression in intermediate age-related macular degeneration (AMD) with changes on fundus photography and fundus autofluorescence (FAF) imaging. Prospective observational case series. Fundus images from 58 eyes (in 58 patients) with intermediate AMD and large drusen were assessed over 2 years for areas of drusen regression which exceeded the area of circle C1 (diameter 125μm; Age-Related Eye Disease Study grading protocol). Manual segmentation and computer-based image analysis were used to detect and delineate areas of drusen regression. Delineated regions were graded as to their appearance on fundus photographs and FAF images, and changes in FAF signals were graded manually and quantitated using automated image analysis. Drusen regression was detected in approximately half of study eyes using manual (48%) and computer-assisted (50%) techniques. At year 2, the clinical appearance of areas of drusen regression on fundus photography was mostly unremarkable, with a majority of eyes (71%) demonstrating no detectable clinical abnormalities, and the remainder (29%) showing minor pigmentary changes. However, drusen regression areas were associated with local changes in FAF that were significantly more prominent than changes on fundus photography. A majority of eyes (64–66%) demonstrated a predominant decrease in overall FAF signal, while 14–21% of eyes demonstrated a predominant increase in overall FAF signal. FAF imaging demonstrated that drusen regression in intermediate AMD was often accompanied with changes in local autofluorescence signal. Drusen regression may be associated with concurrent structural and physiological changes in the outer retina.
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DOI：
10.1097/iae.0b013e318242b949
发表时间：
2012-09
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Hartmann KI;Gomez ML;Bartsch DU;Schuster AK;Freeman WR
通讯作者：
Freeman WR
影响因子：
--
作者：
Friberg, Thomas R.;Brennen, Peter M.;Musch, David C.
通讯作者：
Musch, David C.
影响因子：
--
作者：
Fleckenstein, Monika;Issa, Peter Charbel;Holz, Frank G.
通讯作者：
Holz, Frank G.
影响因子：
13.7
作者：
Little, HL;Showman, JM;Brown, BW
通讯作者：
Brown, BW
影响因子：
--
作者：
BRESSLER, NM;MUNOZ, B;WEST, SK
通讯作者：
WEST, SK