Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors.
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors.
复制标题
RIG-I样受体介导的信号调节：宿主和病毒因子之间的相互作用。
DOI：
10.1038/s41423-020-00602-7
复制
发表时间：
2021-03
影响因子：
24.1
通讯作者：
Yoneyama M
中科院分区：
文献类型：
--
作者：
Onomoto K;Onoguchi K;Yoneyama M
视黄酸诱导基因I（RIG-I）样受体（RLR）是在先天性抗病毒免疫中起重要作用的RNA传感器分子。在由人类基因组编码的三种RLR中，RIG-I和黑素瘤分化相关基因5（其含有N-末端胱天蛋白酶募集结构域）在检测到病毒感染细胞的细胞质中的病毒RNA时被激活。活化的RLR通过与线粒体抗病毒信号蛋白的相互作用诱导下游信号传导，并激活I型和III型干扰素和炎性细胞因子的产生。最近的研究表明，TLR介导的信号转导是通过与内源性RNA和宿主蛋白的相互作用来调节的，例如参与应激反应和翻译后修饰的那些。由于TLR介导的细胞因子产生也参与获得性免疫的调节，因此TLR介导的信号传导的失调与自身免疫性和自身炎症性疾病相关。此外，TLR介导的信号传导可能参与了在冠状病毒疾病2019中观察到的异常细胞因子产生。自2004年发现RLR以来，在了解RLR介导的信号通路的激活和调节的机制方面取得了重大进展。在这里，我们回顾了最新的进展，在理解受调节的RNA识别和信号激活的RLRs，侧重于各种宿主和病毒因子之间的相互作用。
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that play essential roles in innate antiviral immunity. Among the three RLRs encoded by the human genome, RIG-I and melanoma differentiation-associated gene 5, which contain N-terminal caspase recruitment domains, are activated upon the detection of viral RNAs in the cytoplasm of virus-infected cells. Activated RLRs induce downstream signaling via their interactions with mitochondrial antiviral signaling proteins and activate the production of type I and III interferons and inflammatory cytokines. Recent studies have shown that RLR-mediated signaling is regulated by interactions with endogenous RNAs and host proteins, such as those involved in stress responses and posttranslational modifications. Since RLR-mediated cytokine production is also involved in the regulation of acquired immunity, the deregulation of RLR-mediated signaling is associated with autoimmune and autoinflammatory disorders. Moreover, RLR-mediated signaling might be involved in the aberrant cytokine production observed in coronavirus disease 2019. Since the discovery of RLRs in 2004, significant progress has been made in understanding the mechanisms underlying the activation and regulation of RLR-mediated signaling pathways. Here, we review the recent advances in the understanding of regulated RNA recognition and signal activation by RLRs, focusing on the interactions between various host and viral factors.
登录
查看更多内容
影响因子：
5.4
作者：
Beauclair, Guillaume;Streicher, Felix;Jouvenet, Nolwenn
通讯作者：
Jouvenet, Nolwenn
影响因子：
56.9
作者：
Broggi, Achille;Ghosh, Sreya;Zanoni, Ivan
通讯作者：
Zanoni, Ivan
影响因子：
8.8
作者：
Chazal, Maxime;Beauclair, Guillaume;Jouvenet, Nolwenn
通讯作者：
Jouvenet, Nolwenn
影响因子：
11.4
作者：
Abdullah, Zeinab;Schlee, Martin;Knolle, Percy A.
通讯作者：
Knolle, Percy A.
影响因子：
30.5
作者：
Chan YK;Gack MU
通讯作者：
Gack MU