Degradation of aqueous synthesized CdTe/ZnS quantum dots in mice: differential blood kinetics and biodistribution of cadmium and tellurium.
Degradation of aqueous synthesized CdTe/ZnS quantum dots in mice: differential blood kinetics and biodistribution of cadmium and tellurium.
复制标题
小鼠体内水相合成 CdTe/ZnS 量子点的降解：镉和碲的微分血液动力学和生物分布
DOI：
10.1186/1743-8977-10-37
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发表时间：
2013-08-06
影响因子：
10
通讯作者：
Sun Z
中科院分区：
文献类型：
--
作者：
Liu N;Mu Y;Chen Y;Sun H;Han S;Wang M;Wang H;Li Y;Xu Q;Huang P;Sun Z
BackgroundQuantum dots (QDs) have been used as novel fluorescent nanoprobes for various bioapplications. The degradation of QDs, and consequent release of free cadmium ions, have been suggested to be the causes of their overall toxicity. However, in contrast to sufficient investigations regarding the biological fate of QDs, a paucity of studies have reported their chemical fatein vivo. Therefore, the overall aim of our study was to understand the chemical fate of QDsin vivoand explore analytical techniques or methods that could be used to define the chemical fate of QDsin vivo.MethodsMale ICR mice were administered a single intravenous dose (0.2 μmol/kg) of aqueous synthesized CdTe/ZnS aqQDs. Inductively coupled plasma-mass spectrometry (ICP-MS) was used to simultaneously measure the concentrations of cadmium (Cd) and tellurium (Te) in the blood and tissues over the course of a 28 day period. We compared the blood kinetic parameters and biodistributions of Cd and Te, and used the molar ratio of Cd:Te as a marker for QDs degradation.ResultsCd and Te display different blood kinetics and biodistribution profiles. The Cd:Te ratio in the blood did not vary significantly within the first hour compared with intact CdTe/ZnS aqQDs. The Cd:Te ratio decreased gradually over time from the 6 h time point on. Cd accumulated in the liver, kidneys, and spleen. Te was distributed primarily to the kidneys. Sharp time-dependent increases in the Cd:Te ratio were found in liver tissues.ConclusionsQDs can undergo degradationin vivo.In vitro, QDs are chemically stable and do not elicit the same biological responses or consequences as they doin vivo. Our methods might provide valuable information regarding the degradation of QDsin vivoand may enable the design and development of QDs for biological and biomedical applications.
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影响因子：
3.5
作者：
Pi QM;Zhang WJ;Zhou GD;Liu W;Cao Y
通讯作者：
Cao Y
影响因子：
2.5
作者：
Han, Ying;Xie, Guangyun;Huang, Peili
通讯作者：
Huang, Peili
影响因子：
3.1
作者：
Kennel, Stephen J.;Woodward, Jonathan D.;Mirzadeh, Saed
通讯作者：
Mirzadeh, Saed
影响因子：
3.8
作者：
Liu, J;Liu, YP;Klaassen, CD
通讯作者：
Klaassen, CD
DOI：
10.1016/j.cbpc.2009.05.002
发表时间：
2009-08-01
影响因子：
3.9
作者：
Peyrot, Caroline;Gagnon, Christian;Sauve, Sebastien
通讯作者：
Sauve, Sebastien