Mesoporous Polydopamine Loaded Pirfenidone Target to Fibroblast Activation Protein for Pulmonary Fibrosis Therapy.
Mesoporous Polydopamine Loaded Pirfenidone Target to Fibroblast Activation Protein for Pulmonary Fibrosis Therapy.
复制标题
负载吡非尼酮的介孔聚多巴胺靶向成纤维细胞活化蛋白用于肺纤维化治疗
DOI：
10.3389/fbioe.2022.920766
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发表时间：
2022
影响因子：
5.7
通讯作者：
Wang, Xinlu
中科院分区：
文献类型：
--
作者：
Fang, Qi;Liu, Shaoyu;Cui, Jiangyu;Zhao, Ruiyue;Han, Qian;Hou, Peng;Li, Youcai;Lv, Jie;Zhang, Xiaoyao;Luo, Qun;Wang, Xinlu
关键词：
成纤维细胞活化蛋白（fibroblast activation protein，FAP）是一种在肺纤维化中过度表达的活化成纤维细胞的跨膜蛋白，近年来被认为是诊断和治疗肺纤维化的新靶点。本研究以制备简单、易于修饰的介孔聚多巴胺（MPDA）为载体，负载抗肺纤维化药物吡非尼酮（PFD）和连接FAP抑制剂（FAPI），实现肺纤维化治疗的病灶靶向给药。我们发现PFD@MPDA-FAPI具有良好的生物相容性和抗纤维化性能，当ICG标记MPDA-FAPI时，通过近红外成像可以观察到纳米药物在体内纤维化肺中的积聚，并且PFD@MPDA-FAPI的体内抗纤维化性能也优于纯PFD和PFD@MPDA;因此，本研究开发的易于生产且生物相容的纳米药物PFD@MPDA-FAPI有望在肺纤维化抗纤维化治疗中进一步临床转化。
Recently, fibroblast activation protein (FAP), an overexpressed transmembrane protein of activated fibroblast in pulmonary fibrosis, has been considered as the new target for diagnosing and treating pulmonary fibrosis. In this work, mesoporous polydopamine (MPDA), which is facile prepared and easily modified, is developed as a carrier to load antifibrosis drug pirfenidone (PFD) and linking FAP inhibitor (FAPI) to realize lesion-targeted drug delivery for pulmonary fibrosis therapy. We have found that PFD@MPDA-FAPI is well biocompatible and with good properties of antifibrosis, when ICG labels MPDA-FAPI, the accumulation of the nanodrug at the fibrosis lung in vivo can be observed by NIR imaging, and the antifibrosis properties of PFD@MPDA-FAPI in vivo were also better than those of pure PFD and PFD@MPDA; therefore, the easily produced and biocompatible nanodrug PFD@MPDA-FAPI developed in this study is promising for further clinical translations in pulmonary fibrosis antifibrosis therapy.
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影响因子：
2.3
作者：
Liu B;Yang W;Che C;Liu J;Si M;Gong Z;Gao R;Yang G
通讯作者：
Yang G
DOI：
10.1016/j.biocel.2020.105802
发表时间：
2020-09-01
影响因子：
4
作者：
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通讯作者：
Prele, Cecilia M.
影响因子：
5.1
作者：
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通讯作者：
Ozacar, Mahmut
影响因子：
9.5
作者：
Seth A;Gholami Derami H;Gupta P;Wang Z;Rathi P;Gupta R;Cao T;Morrissey JJ;Singamaneni S
通讯作者：
Singamaneni S
DOI：
10.1164/rccm.2009-040gl
发表时间：
2011-03-15
影响因子：
24.7
作者：
Raghu, Ganesh;Collard, Harold R.;Schuenemann, Holger J.
通讯作者：
Schuenemann, Holger J.