Polydopamine-Mesoporous Silica Core-Shell Nanoparticles for Combined Photothermal Immunotherapy.
Polydopamine-Mesoporous Silica Core-Shell Nanoparticles for Combined Photothermal Immunotherapy.
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DOI：
10.1021/acsami.0c10781
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发表时间：
2020-09-23
影响因子：
9.5
通讯作者：
Singamaneni S
中科院分区：
文献类型：
--
作者：
Seth A;Gholami Derami H;Gupta P;Wang Z;Rathi P;Gupta R;Cao T;Morrissey JJ;Singamaneni S
癌症免疫治疗涉及一系列事件，最终导致细胞毒性免疫细胞有效地识别和摧毁癌细胞。响应性纳米材料能够在时空上协调各种免疫事件，从而建立高效、持久的抗肿瘤免疫反应，是克服现有癌症免疫疗法相关挑战的一个有吸引力的平台。在这里，我们报道了一种多功能的近红外(NIR)响应型核壳纳米粒子，它能够(I)光热消融癌细胞以产生肿瘤相关抗原(TAA)和(Ii)触发免疫调节药物(Gardiquimod)的释放，以启动一系列免疫学事件。这些纳米结构的核心是作为光热剂的多巴胺纳米颗粒，外壳是作为药物载体的介孔二氧化硅。我们使用一种相变材料作为把关材料，实现TAA和佐剂的同时释放，从而有效地激活抗原提呈细胞(APC)。在小鼠黑色素瘤模型中，由这些纳米结构实现的光热免疫治疗导致原发肿瘤的消退，并显著改善了对继发肿瘤的抑制。这些生物相容、可生物降解和对近红外响应的核壳纳米结构同时提供有效载荷并导致癌细胞的光热消融。我们的结果表明，响应性纳米材料在产生高度协同的光热免疫治疗反应方面具有潜力。
Cancer immunotherapy involves a cascade of events that ultimately leads to cytotoxic immune cells effectively identifying and destroying cancer cells. Responsive nanomaterials, which enable spatiotemporal orchestration of various immunological events for mounting a highly potent and long-lasting anti-tumor immune response, are an attractive platform to overcome challenges associated with existing cancer immunotherapies. Here, we report a multifunctional near infrared (NIR)-responsive core-shell nanoparticle, which enables (i) photothermal ablation of cancer cells for generating tumor associated antigen (TAA) and (ii) triggered release of an immunomodulatory drug (gardiquimod) for starting a series of immunological events. The core of these nanostructures is composed of polydopamine nanoparticle, which serves as a photothermal agent, and the shell is made of mesoporous silica, which serves as a drug carrier. We employed a phase-change material as gatekeeper to achieve concurrent release of both TAA and adjuvant, thus efficiently activating the antigen presenting cells (APCs). Photothermal-immunotherapy enabled by these nanostructures resulted in regression of primary tumor and significantly improved inhibition of secondary tumor in a mouse melanoma model. These biocompatible, biodegradable, and NIR-responsive core-shell nanostructures simultaneously deliver payload and cause photothermal ablation of the cancer cells. Our results demonstrate potential of responsive nanomaterials in generating highly synergistic photothermal-immunotherapeutic response.
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影响因子：
15
作者：
Moon, Geon Dae;Choi, Sung-Wook;Cai, Xin;Li, Weiyang;Cho, Eun Chul;Jeong, Unyong;Wang, Lihong V.;Xia, Younan
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影响因子：
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