Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates.
Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates.
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DOI：
10.1016/j.diff.2013.05.001
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发表时间：
2013-10
期刊：
影响因子：
2.9
通讯作者：
Discher, Dennis E.
中科院分区：
文献类型：
--
作者：
Shin, Jae-Won;Swift, Joe;Ivanovska, Irena;Spinier, Kyle R.;Buxboim, Amnon;Discher, Dennis E.
成体干细胞和祖细胞因其临床应用以及其揭示对微环境因素的深度敏感性的潜力而引起极大兴趣。骨髓是至少两种类型干细胞的利基，原型是造血干细胞/祖细胞（HSC/Ps），几十年来已经挽救了成千上万的患者。在骨髓中，HSC/Ps在功能上与骨髓基质细胞相互作用，所述骨髓基质细胞通常被称为间充质干细胞（MSC）或其衍生物。肌球蛋白和基质弹性极大地影响MSC功能，并且这些机械生物学因素现在正在用HSC/Ps在体外和体内进行探索。还出现的是作为一个机械敏感的细胞器，是半渗透的转录因子，修改细胞质mechanobiological途径进入核的核的作用。由于设想的诱导多能干细胞和胚胎干细胞的治疗通常涉及体外定向成成体干细胞或祖细胞，因此对干细胞机械生物学的非常深入的理解对于这些多能细胞的进展至关重要。
Adult stem cells and progenitors are of great interest for their clinical application as well as their potential to reveal deep sensitivities to microenvironmental factors. The bone marrow is a niche for at least two types of stem cells, and the prototype is the hematopoietic stem cell/progenitors (HSC/Ps), which have saved many thousands of patients for several decades now. In bone marrow, HSC/Ps interact functionally with marrow stromal cells that are often referred to as mesenchymal stem cells (MSCs) or derivatives thereof. Myosin and matrix elasticity greatly effect MSC function, and these mechanobiological factors are now being explored with HSC/Ps both in vitro and in vivo. Also emerging is a role for the nucleus as a mechanically sensitive organelle that is semi-permeable to transcription factors which are modified for nuclear entry by cytoplasmic mechanobiological pathways. Since therapies envisioned with induced pluripotent stem cells and embryonic stem cells generally involve in vitro commitment to an adult stem cell or progenitor, a very deep understanding of stem cell mechanobiology is essential to progress with these multi-potent cells.
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DOI：
10.1073/pnas.192291499
发表时间：
2002-09-17
影响因子：
11.1
作者：
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作者：
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