Functional brain networks before the onset of psychosis: A prospective fMRI study with graph theoretical analysis.
Functional brain networks before the onset of psychosis: A prospective fMRI study with graph theoretical analysis.
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DOI：
10.1016/j.nicl.2012.09.008
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发表时间：
2012
影响因子：
4.2
通讯作者：
Turkheimer, Federico E.
中科院分区：
文献类型：
--
作者：
Lord, Louis-David;Allen, Paul;Expert, Paul;Howes, Oliver;Broome, Matthew;Lambiotte, Renaud;Fusar-Poli, Paolo;Valli, Isabel;McGuire, Philip;Turkheimer, Federico E.
具有高危精神状态（ARMS）的个体患精神病的风险明显高于一般人群。然而，目前还不可能仅从临床评估来预测哪些ARMS个体会发展为精神病。比较有和没有发生精神病的ARMS受试者可以揭示哪些因素对疾病的发病至关重要。在本研究中，37例ARMS患者在初次转诊后进行了至少24个月的临床随访。功能性MRI数据是在随访期开始时收集的，在执行一项已知会调动额叶网络并在精神病中受损的执行任务期间。图理论分析用于比较扫描后出现精神障碍的ARMS患者（ARMS- t）与在同一随访期间未发病的患者（ARMS- nt）和年龄匹配的对照组的功能性脑网络组织。研究了每个群体的代表网络的全局属性（密度、效率、全局平均路径长度）以及网络节点对系统组织的区域特定贡献（度、farness-centrality、between -centrality）。我们的分析集中在背前扣带皮层（ACC）上，这是一个已知的支持执行功能的区域，在ARMS患者中结构和功能受损。在全球网络组织中没有组间差异的情况下，我们报告了相对于ARMS-NT和对照组，ARMS-T组ACC的拓扑中心性显著降低。这些结果提供了大脑功能组织异常早于精神病发病的证据，并表明ACC拓扑中心性的丧失是向精神病过渡的潜在生物标志物。►对来自fMRI的图理论数据进行组间分析。►比较有和没有随后转变为精神病的高危精神状态患者。►有后续疾病表现的高危患者网络拓扑结构异常。随着疾病进展，ACC在网络中的拓扑中心性在ARMS患者中降低。►全球网络财产在所有有风险的科目中得到保护。
Individuals with an at-risk mental state (ARMS) have a risk of developing a psychotic disorder significantly greater than the general population. However, it is not currently possible to predict which ARMS individuals will develop psychosis from clinical assessment alone. Comparison of ARMS subjects who do, and do not, develop psychosis can reveal which factors are critical for the onset of illness. In the present study, 37 patients with an ARMS were followed clinically at least 24 months subsequent to initial referral. Functional MRI data were collected at the beginning of the follow-up period during performance of an executive task known to recruit frontal lobe networks and to be impaired in psychosis. Graph theoretical analysis was used to compare the organization of a functional brain network in ARMS patients who developed a psychotic disorder following the scan (ARMS-T) to those who did not become ill during the same follow-up period (ARMS-NT) and aged-matched controls. The global properties of each group's representative network were studied (density, efficiency, global average path length) as well as regionally-specific contributions of network nodes to the organization of the system (degree, farness-centrality, betweenness-centrality). We focused our analysis on the dorsal anterior cingulate cortex (ACC), a region known to support executive function that is structurally and functionally impaired in ARMS patients. In the absence of between-group differences in global network organization, we report a significant reduction in the topological centrality of the ACC in the ARMS-T group relative to both ARMS-NT and controls. These results provide evidence that abnormalities in the functional organization of the brain predate the onset of psychosis, and suggest that loss of ACC topological centrality is a potential biomarker for transition to psychosis. ► Performed between-groups analysis of graph theoretical data derived from fMRI. ► Compared at-risk mental state patients with and without subsequent transition to psychosis. ► At-risk patients with subsequent disease manifestation show abnormal network topology. ► ACC’s topological centrality in the network is decreased in ARMS patients with disease progression. ► Global network properties are preserved in all at-risk subjects.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
4.8
作者：
Honey, Christopher J.;Sporns, Olaf
通讯作者：
Sporns, Olaf
影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC