Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy.
Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy.
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水杨酸盐和吡id胺对糖尿病性肾病的预防作用。
DOI：
10.1155/2016/1786789
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发表时间：
2016
影响因子：
4.3
通讯作者：
Yamamoto Y
中科院分区：
文献类型：
--
作者：
Abouzed TK;Munesue S;Harashima A;Masuo Y;Kato Y;Khailo K;Yamamoto H;Yamamoto Y
客观的。糖尿病肾病是长期糖尿病患者的一种危及生命的并发症。血流动力学、炎症和代谢因素被认为是糖尿病肾病的发生因素。在这项研究中，我们评估了与吡哆胺相比，水杨酸盐的药物干预是否可以预防小鼠糖尿病肾病。方法。采用在胰腺β细胞中过度表达诱导型一氧化氮合酶的雄性小鼠作为糖尿病模型。给予水杨酸盐（3g/kg饮食）或吡哆胺（1g/L饮用水；~200mg/kg/天）16周，以评估糖尿病肾病的发展。使用长效胰岛素（Levemir 2 单位/kg，每天两次）治疗作为对照。结果。尽管吡哆胺对较高的血糖水平没有显着影响，但肾病的早期至晚期指标有所减弱，包括肾脏肿大、蛋白尿、血清肌酐增加、肾小球硬化以及炎症和促纤维化基因表达。水杨酸盐对糖尿病肾病显示出与吡哆胺类似的有益作用，包括降低血糖水平和抑制巨噬细胞浸润到肾脏。仅在水杨酸盐治疗组中发现巨噬细胞浸润肾脏的减弱和抗糖化酶乙二醛酶 1 基因表达的上调。结论。水杨酸盐和吡哆胺治疗可以预防小鼠糖尿病肾病的发展，因此，这将是治疗糖尿病患者肾脏问题的一种潜在有用的治疗策略。
Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice. Methods. Male mice overexpressing inducible nitric oxide synthase in pancreatic β-cells were employed as a diabetic model. Salicylate (3 g/kg diet) or pyridoxamine (1 g/L drinking water; ~200 mg/kg/day) was given for 16 weeks to assess the development of diabetic nephropathy. Treatment with long-acting insulin (Levemir 2 units/kg twice a day) was used as a control. Results. Although higher blood glucose levels were not significantly affected by pyridoxamine, early to late stage indices of nephropathy were attenuated, including kidney enlargement, albuminuria, and increased serum creatinine, glomerulosclerosis, and inflammatory and profibrotic gene expressions. Salicylate showed beneficial effects on diabetic nephropathy similar to those of pyridoxamine, which include lowering blood glucose levels and inhibiting macrophage infiltration into the kidneys. Attenuation of macrophage infiltration into the kidneys and upregulation of antiglycating enzyme glyoxalase 1 gene expression were found only in the salicylate treatment group. Conclusions. Treatment with salicylate and pyridoxamine could prevent the development of diabetic nephropathy in mice and, therefore, would be a potentially useful therapeutic strategy against kidney problems in patients with diabetes.
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影响因子：
3.2
作者：
Yamamoto Y;Yamamoto H
通讯作者：
Yamamoto H
影响因子：
39.2
作者：
Goldfine AB;Fonseca V;Jablonski KA;Chen YD;Tipton L;Staten MA;Shoelson SE;Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
通讯作者：
Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team
影响因子：
15.9
作者：
Yamamoto, Y;Kato, I;Yamamoto, H
通讯作者：
Yamamoto, H
影响因子：
39.2
作者：
Goldfine AB;Fonseca V;Jablonski KA;Pyle L;Staten MA;Shoelson SE;TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team
通讯作者：
TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team
影响因子：
4.8
作者：
Ohashi, S;Abe, H;Doi, T
通讯作者：
Doi, T