Pro-inflammatory cytokines associate with NETosis during sickle cell vaso-occlusive crises.
Pro-inflammatory cytokines associate with NETosis during sickle cell vaso-occlusive crises.
复制标题
DOI：
10.1016/j.cyto.2019.154933
复制
发表时间：
2020-03
期刊：
影响因子：
3.8
通讯作者：
Thein SL
中科院分区：
文献类型：
--
作者：
Barbu EA;Mendelsohn L;Samsel L;Thein SL
Recurring episodes of acute pain, also referred to as vaso-occlusive crises (VOC), are characteristic of sickle cell disease (SCD), during which pro-inflammatory cytokines, chemokines, adhesion markers and white cell count, some already elevated at steady state, increase further. Hydroxyurea (HU) is licensed by the FDA for reducing frequency of VOCs in SCD; increased fetal hemoglobin (HbF) together with reduction of the neutrophil count and circulating inflammatory markers, contribute to its clinical efficacy. Here, using paired plasma samples from HbSS patients (in steady-state and VOC) we determined that despite HU treatment, the SCD environment remained highly inflammatory and particularly at VOC, triggered neutrophil activity. While neutrophil extracellular traps (NETs) induction by the steady state plasmas were comparable to that of plasma from healthy donors, the NETs response triggered by crisis plasmas was significantly increased over that of the steady state (P = 0.0124*). Levels of IL-6 and IL-1α, IL-1ra/IL1F3 and adhesion molecule P-selectin were significantly increased in the VOC plasma when compared with steady state plasma. Higher levels of IL-6 and IL-1ra were also found in the crises samples that yielded an increased NETs response suggesting that increased NETs production associated with increased levels of the inflammatory products of the IL-6 family and regulators of IL-1 family of cytokines during sickle VOCs.
登录
查看更多内容
影响因子：
158.5
作者：
PLATT, OS;BRAMBILLA, DJ;KLUG, PP
通讯作者：
KLUG, PP
影响因子：
5.5
作者：
Lanaro, C.;Franco-Penteado, C. F.;Costa, F. F.
通讯作者：
Costa, F. F.
影响因子：
20.3
作者：
Chen, Grace;Zhang, Dachuan;Frenette, Paul S.
通讯作者：
Frenette, Paul S.
DOI：
10.1056/nejmoa1611770
发表时间：
2017-02-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ataga KI;Kutlar A;Kanter J;Liles D;Cancado R;Friedrisch J;Guthrie TH;Knight-Madden J;Alvarez OA;Gordeuk VR;Gualandro S;Colella MP;Smith WR;Rollins SA;Stocker JW;Rother RP
通讯作者：
Rother RP
影响因子：
2.8
作者：
Keikhaei, Bijan;Mohseni, Ali Reza;Solgi, Ghasem
通讯作者：
Solgi, Ghasem