Does bilateral damage to the human amygdala produce autistic symptoms?
Does bilateral damage to the human amygdala produce autistic symptoms?
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人类杏仁核的双侧损伤是否会产生自闭症症状？
DOI：
10.1007/s11689-010-9056-1
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发表时间：
2010
影响因子：
4.9
通讯作者：
Adolphs,Ralph
中科院分区：
文献类型：
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作者：
Paul,LynnK;Corsello,Christina;Tranel,Daniel;Adolphs,Ralph
自闭症的一个主要神经学假说假设杏仁核功能障碍。这一假说得到了解剖学和神经影像学研究的大量支持。双侧杏仁核损伤的个体在社会认知的某些方面表现出障碍。这些障碍与自闭症患者报告的障碍有着有趣的相似之处，例如对面部情绪的识别受损、心理理论能力受损、无法将眼睛注视在脸上以及难以调节与他人的个人空间距离。然而，这些神经系统病例以前从未被直接评估过，看他们是否符合自闭症谱系障碍（ASD）的标准。在这里，我们进行了这样的调查，在两个罕见的参与者与发展开始双边杏仁核病变。我们进行了全面的临床检查，以及自闭症诊断观察表（ADOS），社会反应量表（SRS），以及其他几个标准化的问卷调查。将这两名杏仁核病变患者的结果与健康人群和ASD患者的已发表标准进行比较。在一系列不同的测量中，杏仁核损伤的参与者都没有表现出任何自闭症的证据。研究结果表明，孤立的杏仁核损伤不足以产生自闭症症状。相反，我们认为杏仁核和其他结构之间的异常连接可能会在网络层面导致自闭症症状。
A leading neurological hypothesis for autism postulates amygdala dysfunction. This hypothesis has considerable support from anatomical and neuroimaging studies. Individuals with bilateral amygdala lesions show impairments in some aspects of social cognition. These impairments bear intriguing similarity to those reported in people with autism, such as impaired recognition of emotion in faces, impaired theory of mind abilities, failure to fixate eyes in faces, and difficulties in regulating personal space distance to others. Yet such neurological cases have never before been assessed directly to see if they meet criteria for autism spectrum disorders (ASD). Here we undertook such an investigation in two rare participants with developmental-onset bilateral amygdala lesions. We administered a comprehensive clinical examination, as well as the Autism Diagnostic Observation Schedule (ADOS), the Social Responsiveness Scale (SRS), together with several other standardized questionnaires. Results from the two individuals with amygdala lesions were compared with published norms from both healthy populations as well as from people with ASD. Neither participant with amygdala lesions showed any evidence of autism across the array of different measures. The findings demonstrate that amygdala lesions in isolation are not sufficient for producing autistic symptoms. We suggest instead that it may be abnormal connectivity between the amygdala and other structures that contributes to autistic symptoms at a network level.
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影响因子：
--
作者：
A. Damasio;R. Maurer
通讯作者：
R. Maurer
影响因子：
14.5
作者：
Pierce, K;Haist, F;Courchesne, E
通讯作者：
Courchesne, E
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影响因子：
1
作者：
U. Kucuk;I. Erdoğan;U. Bayol;Nazife Hacioglu;I. Cukurova;C. Bicakci
通讯作者：
C. Bicakci
影响因子：
56.9
作者：
A. Bechara;D. Tranel;H. Damasio;R. Adolphs;C. Rockland;A. Damasio
通讯作者：
A. Bechara;D. Tranel;H. Damasio;R. Adolphs;C. Rockland;A. Damasio
DOI：
10.1037/h0058870
发表时间：
1954-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ROSVOLD, HE;MIRSKY, AF;PRIBRAM, KH
通讯作者：
PRIBRAM, KH