Inhibition of the OAS/RNase L pathway by viruses.
Inhibition of the OAS/RNase L pathway by viruses.
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DOI：
10.1016/j.coviro.2015.07.002
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发表时间：
2015-12
影响因子：
5.9
通讯作者：
Michiels T
中科院分区：
文献类型：
--
作者：
Drappier M;Michiels T
OAS/RNase L途径是最早表征的IFN效应子途径之一。2-5A分子连接两个RNase L原体的锚蛋白结构域以激活该酶。病毒进化出多种策略来逃避OAS/RNase L宿主反应。病毒的拮抗作用突出了RNase L作为抗病毒防御的重要性。为什么有些病毒作用于通路的上游，而另一些则作用于通路的下游？OAS/RNase L系统是最早表征的干扰素效应途径之一。它依赖于寡腺苷酸合成酶（OAS）合成短的寡核苷酸，作为第二信使激活潜伏的细胞RNA酶L。病毒已经发展出多种策略来逃避其抗病毒作用。这强调了OAS/RNase L途径在抗病毒防御中的重要性。病毒蛋白如流感病毒A的NS 1蛋白作用于该途径的上游，而其他病毒蛋白如泰勒病毒L* 蛋白作用于下游。病毒使用的逃逸策略的多样性可能源于它们对OAS/RNase L和其他抗病毒途径的相对易感性，这可能取决于它们的宿主和细胞嗜性。
The OAS/RNase L pathway was one of the first characterized IFN effector pathways. 2–5A molecules link ankyrin domains of two RNase L protomers to activate the enzyme. Viruses evolved a variety of strategies to escape the OAS/RNase L host response. Antagonism by viruses highlights the importance of RNase L as an antiviral defense. Why do some viruses act upstream and others downstream of the pathway? The OAS/RNase L system was one of the first characterized interferon effector pathways. It relies on the synthesis, by oligoadenylate synthetases (OAS), of short oligonucleotides that act as second messengers to activate the latent cellular RNase L. Viruses have developed diverse strategies to escape its antiviral effects. This underscores the importance of the OAS/RNase L pathway in antiviral defenses. Viral proteins such as the NS1 protein of Influenza virus A act upstream of the pathway while other viral proteins such as Theiler's virus L* protein act downstream. The diversity of escape strategies used by viruses likely stems from their relative susceptibility to OAS/RNase L and other antiviral pathways, which may depend on their host and cellular tropism.
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DOI：
10.1073/pnas.76.6.2600
发表时间：
1979-01-01
影响因子：
11.1
作者：
NILSEN, TW;BAGLIONI, C
通讯作者：
BAGLIONI, C
DOI：
10.1073/pnas.89.11.4825
发表时间：
1992-06-01
影响因子：
11.1
作者：
CHANG, HW;WATSON, JC;JACOBS, BL
通讯作者：
JACOBS, BL
影响因子：
64.8
作者：
KERR, IM;BROWN, RE;HOVANESSIAN, AG
通讯作者：
HOVANESSIAN, AG
DOI：
10.1046/j.1432-1327.1998.2540248.x
发表时间：
1998-06-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Martinand, C;Salehzada, T;Bisbal, C
通讯作者：
Bisbal, C
影响因子：
5.4
作者：
Martinand, C;Montavon, C;Bisbal, C
通讯作者：
Bisbal, C