APOL1, Sickle Cell Trait, and CKD in the Jackson Heart Study.
APOL1, Sickle Cell Trait, and CKD in the Jackson Heart Study.
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DOI：
10.1016/j.xkme.2021.05.004
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发表时间：
2021-11
期刊：
影响因子：
3.9
通讯作者：
Katz R
中科院分区：
文献类型：
--
作者：
Young BA;Wilson JG;Reiner A;Kestenbaum B;Franceschini N;Bansal N;Correa A;Himmelfarb J;Katz R
载脂蛋白L1 （APOL1）高危变异与非裔美国人患慢性肾脏疾病（CKD）的风险增加有关。对于只有1个APOL1风险变异的非裔美国人发生CKD和肾衰竭（终末期肾病[ESKD]）的风险，或者这种风险是否被镰状细胞特征所改变，我们所知的较少。杰克逊心脏研究是一项基于社区的纵向队列研究。杰克逊心脏研究中自我报告的非裔美国人（n = 5306）。APOL1 G1和G2基因型与镰状细胞性状的关系。突发CKD（估计肾小球滤过率< 60 mL/min/1.73 m2）、蛋白尿（尿白蛋白-肌酐比值≥30 mg/g）、肾功能持续快速下降（下降≥30%）和突发ESKD。多变量线性和逻辑回归，以及Cox比例风险模型，校正了年龄、性别、高血压、糖尿病、祖先信息标记和镰状细胞特征。在2300名参与者中，41.3%为零，45.1%为1,13.6%为2 APOL1风险变异。8.5%存在镰状细胞性状。与参与者风险零APOL1变体相比,那些2等位基因有一个事件的风险增加蛋白尿(调整人力资源(aHR), 1.88; 95%置信区间,1.04至3.40),ESKD (aHR, 9.05; 95%置信区间,1.79至45.85),事件CKD (aHR, 1.65; 95%置信区间,1.06至2.57),连续下降(β=−1.90;95%可信区间,3.35−−0.45),和快速的肾功能下降(优势比,2.21;95%置信区间,1.22至4.00)调整后的镰状细胞特征,与类似的结果调整后祖先信息标记。有1个APOL1风险变异与CKD结果无关，APOL1与镰状细胞特征没有相互作用。具有APOL1和镰状细胞特征的非裔美国人的单位点招募。1个APOL1风险等位基因的存在与CKD结局的风险增加无关，而2个风险等位基因与蛋白尿、CKD、ESKD和快速持续的肾功能下降有关。需要进一步的研究来确定可能改变高危APOL1基因型患者肾脏不良结局风险的因素。
Apolipoprotein L1 (APOL1) high-risk variants are associated with an increased risk for chronic kidney disease (CKD) among African Americans. Less is known regarding the risk for the development of CKD and kidney failure (end-stage kidney disease [ESKD]) among African Americans with only 1 APOL1 risk variant or whether the risk is modified by sickle cell trait. The Jackson Heart Study is a community-based longitudinal cohort study. Self-reported African Americans in the Jackson Heart Study (n = 5,306). APOL1 G1 and G2 genotypes and sickle cell trait. Incident CKD (estimated glomerular filtration rate < 60 mL/min/1.73 m2), albuminuria (urinary albumin-creatinine ratio ≥ 30 mg/g), continuous and rapid kidney function decline (≥30% decline), and incident ESKD. Multivariable linear and logistic regression, and Cox proportional hazards models adjusted for age, sex, hypertension, diabetes, ancestry informative markers, and sickle cell trait. Of 2,300 participants, 41.3% had zero, 45.1% had 1, and 13.6% had 2 APOL1 risk variants. Sickle cell trait was present in 8.5%. Compared with participants with zero APOL1 risk variants, those with 2 alleles had an increased risk for incident albuminuria (adjusted HR [aHR], 1.88; 95% CI, 1.04 to 3.40), ESKD (aHR, 9.05; 95% CI, 1.79 to 45.85), incident CKD (aHR, 1.65; 95% CI, 1.06 to 2.57), continuous decline (β = −1.90; 95% CI, −3.35 to −0.45), and rapid kidney function decline (OR, 2.21; 95% CI, 1.22 to 4.00) after adjustment for sickle cell trait, with similar results after adjustment for ancestry informative markers. Having 1 APOL1 risk variant was not associated with CKD outcomes and there was no interaction of APOL1 with sickle cell trait. Single-site recruitment of African American individuals with APOL1 and sickle cell trait. The presence of 1 APOL1 risk allele was not associated with increased risk for CKD outcomes, whereas 2 risk alleles were associated with incident albuminuria, CKD, ESKD, and rapid and continuous kidney function decline. Additional studies are needed to determine factors that might alter the risk for adverse kidney outcomes among individuals with high-risk APOL1 genotypes.
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DOI：
10.1126/science.1193032
发表时间：
2010-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Genovese G;Friedman DJ;Ross MD;Lecordier L;Uzureau P;Freedman BI;Bowden DW;Langefeld CD;Oleksyk TK;Uscinski Knob AL;Bernhardy AJ;Hicks PJ;Nelson GW;Vanhollebeke B;Winkler CA;Kopp JB;Pays E;Pollak MR
通讯作者：
Pollak MR
影响因子：
13.6
作者：
Grams, Morgan E.;Rebholz, Casey M.;Coresh, Josef
通讯作者：
Coresh, Josef
影响因子：
13.6
作者：
Friedman, David J.;Kozlitina, Julia;Pollak, Martin R.
通讯作者：
Pollak, Martin R.
DOI：
10.1111/j.1600-6143.2011.03513.x
发表时间：
2011-05
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Reeves-Daniel AM;DePalma JA;Bleyer AJ;Rocco MV;Murea M;Adams PL;Langefeld CD;Bowden DW;Hicks PJ;Stratta RJ;Lin JJ;Kiger DF;Gautreaux MD;Divers J;Freedman BI
通讯作者：
Freedman BI
影响因子：
9.8
作者：
Bick, Alexander G.;Flannick, Jason;Seidman, Christine
通讯作者：
Seidman, Christine