Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review.
Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review.
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DOI:
10.3390/nu13113751
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发表时间:
2021-10-23
期刊:
影响因子:
5.9
通讯作者:
De Plaen IG
中科院分区:
文献类型:
--
作者:
York DJ;Smazal AL;Robinson DT;De Plaen IG
Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.
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DOI:
10.1038/labinvest.2011.167
发表时间:
2012-03
期刊:
Laboratory investigation; a journal of technical methods and pathology
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