Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review.

Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review.
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DOI:
10.3390/nu13113751
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发表时间:
2021-10-23
期刊:
影响因子:
5.9
通讯作者:
De Plaen IG
De Plaen IG
中科院分区:
医学2区
文献类型:
--
作者:
York DJ;Smazal AL;Robinson DT;De Plaen IG

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越来越多的证据表明母乳对坏死性小肠结肠炎(NEC)具有保护作用。人乳的这些特性来自影响肠道生长、屏障功能、微血管发育和免疫成熟的生物活性化合物。在这些保护性化合物中,生长因子在出生后早期以相对高的浓度分泌到乳汁中,此时新生儿最容易患NEC。本文综述了目前的知识人乳生长因子及其相关的NEC预防的作用机制。它还将讨论这些生长因子与人乳巴氏灭菌的稳定性,以及它们作为婴儿配方奶粉补充剂的潜力,目的是预防NEC。
Growing evidence demonstrates human milk’s protective effect against necrotizing enterocolitis (NEC). Human milk derives these properties from biologically active compounds that influence intestinal growth, barrier function, microvascular development, and immunological maturation. Among these protective compounds are growth factors that are secreted into milk with relatively high concentrations during the early postnatal period, when newborns are most susceptible to NEC. This paper reviews the current knowledge on human milk growth factors and their mechanisms of action relevant to NEC prevention. It will also discuss the stability of these growth factors with human milk pasteurization and their potential for use as supplements to infant formulas with the goal of preventing NEC.
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