Development of fluorophores for the detection of oligomeric aggregates of amyloidogenic proteins found in neurodegenerative diseases.
Development of fluorophores for the detection of oligomeric aggregates of amyloidogenic proteins found in neurodegenerative diseases.
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DOI：
10.3389/fchem.2023.1343118
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发表时间：
2023
影响因子：
5.5
通讯作者：
Yang, Jerry
中科院分区：
文献类型：
--
作者：
Teppang, Kristine L.;Zhao, Qilin;Yang, Jerry
阿尔茨海默病和帕金森病是全球最常见的两种神经退行性疾病。这些神经退行性疾病具有特征性的晚期症状，可以进行鉴别诊断；然而，它们都存在错误折叠的蛋白质聚集体，在临床表现前几年出现。历史上，研究主要集中在检测高阶聚集体（或淀粉样蛋白）；然而，最近的证据表明，这些蛋白质聚集体的低聚状态在疾病病理学中起着更大的作用，导致检测低聚物以帮助疾病诊断的努力增加。在这篇综述中，我们总结了一些令人兴奋的新进展，在开发荧光探针可以检测存在于阿尔茨海默病和帕金森病患者淀粉样蛋白的低聚物聚集体。
Alzheimer’s disease and Parkinson’s disease are the two most common neurodegenerative diseases globally. These neurodegenerative diseases have characteristic late-stage symptoms allowing for differential diagnosis; however, they both share the presence of misfolded protein aggregates which appear years before clinical manifestation. Historically, research has focused on the detection of higher-ordered aggregates (or amyloids); however, recent evidence has shown that the oligomeric state of these protein aggregates plays a greater role in disease pathology, resulting in increased efforts to detect oligomers to aid in disease diagnosis. In this review, we summarize some of the exciting new developments towards the development of fluorescent probes that can detect oligomeric aggregates of amyloidogenic proteins present in Alzheimer’s and Parkinson’s disease patients.
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