Biomarkers for Alzheimer's Disease Diagnosis.
Biomarkers for Alzheimer's Disease Diagnosis.
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DOI：
10.2174/1567205014666170203125942
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发表时间：
2017
影响因子：
2.1
通讯作者：
Alexiou A
中科院分区：
文献类型：
--
作者：
Mantzavinos V;Alexiou A
预计未来几十年痴呆症人口将急剧增加，与此同时，将建立新的和创新的方法，在疾病的早期阶段提供准确和有效的检测。虽然阿尔茨海默病是痴呆症最常见的原因，但当它被典型诊断时，大量神经元丢失和神经病理损害可能会损害大脑的许多区域。这项研究的目的是调查影响和增加阿尔茨海默病进展的主要危险因素，即使在没有明显记忆障碍的情况下也是如此。讨论了几个潜在的标志物，如氧化应激、金属离子、血管疾病、蛋白质功能障碍和线粒体群体的变化。根据阿尔茨海默病的最新分类，提出了阿尔茨海默病生物标志物的多参数模型。
The dramatic increase in the population with dementia expected in the next decades is accompanied by the establishment of novel and innovated methods that will offer accurate and efficient detection of the disease in its early stages. While Alzheimer’s disease is the most common cause of dementia, by the time it is typically diagnosed, substantial neuronal loss and neuropathological lesions can damage many brain regions. The aim of this study is to investigate the main risk factors that affect and increase Alzheimer’s disease progression over time even in cases with no significant memory impairment present. Several potential markers are discussed such as oxidative stress, metal ions, vascular disorders, protein dysfunctions and alterations in the mitochondrial populations. A multiparametric model of Alzheimer’s biomarkers is presented according to the latest classification of the disease.
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影响因子：
2.5
作者：
Hooper, Claudie;Meimaridou, Eirini;Tavassoli, Mahvash;Melino, Gerry;Lovestone, Simon;Killick, Richard
通讯作者：
Killick, Richard
影响因子：
120.7
作者：
Jansen, Willemijn J.;Ossenkoppele, Rik;Knol, Dirk L.;Tijms, Betty M.;Scheltens, Philip;Verhey, Frans R. J.;Visser, Pieter Jelle
通讯作者：
Visser, Pieter Jelle
影响因子：
2.6
作者：
Dickerson, Bradford C.;Sperling, Reisa A.
通讯作者：
Sperling, Reisa A.
影响因子：
--
作者：
Grundman, M;Petersen, RC;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
9.9
作者：
Dickerson, BC;Salat, DH;Sperling, RA
通讯作者：
Sperling, RA