A human gut microbial gene catalogue established by metagenomic sequencing.
A human gut microbial gene catalogue established by metagenomic sequencing.
复制标题
作者：
为了了解肠道微生物对人类健康和福祉的影响，评估其遗传潜力至关重要。在这里，我们描述了基于Illumina的宏基因组测序，组装和表征330万非冗余微生物基因，来自576.7 Gb序列，来自124个欧洲人的粪便样本。该基因集比人类基因补体大约150倍，包含该群体的绝大多数流行微生物基因，并且可能包括大比例的流行人类肠道微生物基因。这些基因在很大程度上在群体的个体之间共享。超过99%的基因是细菌，这表明整个群体拥有1000至1150种流行的细菌物种，每个人至少有160种这样的物种，这些物种也在很大程度上是共享的。我们定义和描述的最小肠道宏基因组和最小肠道细菌基因组的基因集编码的功能。
To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million nonredundant microbial genes, derived from 576.7 Gb sequence, from faecal samples of 124 European individuals. The gene set, ~150 times larger than the human gene complement, contains an overwhelming majority of the prevalent microbial genes of the cohort and likely includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, suggesting that the entire cohort harbours between 1000 and 1150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions encoded by the gene set.
登录
查看更多内容
影响因子：
4.2
作者：
Metges, CC
通讯作者：
Metges, CC
影响因子：
7
作者：
Li, Ruiqiang;Zhu, Hongmei;Wang, Jun
通讯作者：
Wang, Jun
影响因子：
56.9
作者：
Gill, Steven R.;Pop, Mihai;Nelson, Karen E.
通讯作者：
Nelson, Karen E.
DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI
大肠杆菌K-12的构造框架，单基因敲除突变体：Keio Collection。
影响因子：
9.9
作者：
通讯作者：
--