Roles of FGF20 in dopaminergic neurons and Parkinson's disease.
Roles of FGF20 in dopaminergic neurons and Parkinson's disease.
复制标题
FGF20在多巴胺能神经元和帕金森氏病中的作用。
DOI：
10.3389/fnmol.2013.00015
复制
发表时间：
2013
影响因子：
4.8
通讯作者：
Ohta H
中科院分区：
文献类型：
--
作者：
Itoh N;Ohta H
成纤维细胞生长因子家族由22个成员组成，在发育和代谢中具有不同的功能。FGF20最初被认为是一种新的成纤维细胞生长因子，优先在黑质致密部(SNPC)表达。作用于近端细胞的FGF20通过其受体1c激活丝裂原活化蛋白激酶(MAPK)通路，显著提高培养的多巴胺能神经元的存活率。在帕金森病大鼠模型中，FGF20对多巴胺能神经元的丢失具有显著的保护作用。FGF20的单核苷酸多态与帕金森病的相关性显著，提示FGF20的遗传变异可能是帕金森病的危险因素。神经干细胞和胚胎干细胞被认为是帕金森病恢复性移植策略的细胞来源。FGF20促进这些干细胞分化为多巴胺能神经元，从而减轻帕金森氏病动物模型的神经症状。这些发现表明FGF20对多巴胺能神经元的分化和存活以及帕金森病的病因和治疗具有重要意义。
The fibroblast growth factor (FGF) family comprises 22 members with diverse functions in development and metabolism. Fgf20 was originally identified as a new Fgf preferentially expressed in the substantia nigra pars compacta (SNpc). Fgf20, which acts on proximal cells, significantly enhanced the survival of cultured dopaminergic neurons by activating the mitogen-activated protein kinase (MAPK) pathway through Fgf receptor 1c. In the rat model of Parkinson's disease, Fgf20 afforded significant protection against the loss of dopaminergic neurons. The significant correlation of Parkinson's disease with single-nucleotide polymorphisms in FGF20 indicates that the genetic variability of FGF20 can be a Parkinson's disease risk. Neural and embryonic stem (ES) cells have been considered as cell resources for restorative transplantation strategies in Parkinson's disease. Fgf20 promoted the differentiation of these stem cells into dopaminergic neurons, which attenuated neurological symptoms in animal models of Parkinson's disease. These findings indicate the importance of FGF20 for the differentiation and survival of dopaminergic neurons and the etiology and therapy of Parkinson's disease.
登录
查看更多内容
使用来自多个队列的病例和对照样本进行遗传关联研究的稳健而有效的统计方法
影响因子：
4.4
作者：
Wang M;Wang L;Jiang N;Jia T;Luo Z
通讯作者：
Luo Z
DOI：
10.1006/bbrc.2000.3675
发表时间：
2000-10-22
影响因子：
3.1
作者：
Ohmachi, S;Watanabe, Y;Itoh, N
通讯作者：
Itoh, N
影响因子：
4.2
作者：
Ohmachi, S;Mikami, T;Itoh, N
通讯作者：
Itoh, N
影响因子：
7.5
作者：
Gibson SA;Gao GD;McDonagh K;Shen S
通讯作者：
Shen S
影响因子：
5.3
作者：
Mizuta, Ikuko;Tsunoda, Tatsuhiko;Toda, Tatsushi
通讯作者：
Toda, Tatsushi