Serum FABP4 concentrations decrease after Roux-en-Y gastric bypass but not after intensive medical management.
Serum FABP4 concentrations decrease after Roux-en-Y gastric bypass but not after intensive medical management.
复制标题
roux-en-y胃搭桥术后血清Fabp4浓度降低，但在密集的医疗管理后不降低。
DOI：
10.1016/j.surg.2018.08.007
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发表时间：
2019-03
期刊：
影响因子：
3.8
通讯作者：
Ikramuddin S
中科院分区：
文献类型：
--
作者：
Jahansouz C;Xu H;Kizy S;Thomas AJ;Josephrajan A;Hertzel AV;Foncea R;Connett JC;Billington CJ;Jensen M;Korner J;Bernlohr DA;Ikramuddin S
脂肪酸结合蛋白 4 (FABP4)（一种脂肪组织脂肪酸伴侣）的血清浓度与胰岛素抵抗和心血管危险因素相关。本研究的目的是：（1）评估Roux-en-Y胃绕道手术（RYGB）、强化生活方式改变和医疗管理方案（LS/IMM）、FABP4和患有严重2型糖尿病（T2DM）的肥胖患者代谢参数之间的关系。 (2)评价腹部皮下脂肪和内脏脂肪对FABP4分泌的相对贡献。受试者被随机分配至 LS/IMM (n = 29) 或 LS/IMM 增强 RYGB (n = 34)。检查了 FABP4 与人口统计、代谢参数以及这些值的 12 个月变化之间的关系。获得来自肥胖非糖尿病患者 (n=5) 的内脏和皮下脂肪组织外植体并用毛喉素处理，以评估不同脂肪组织库中 FABP4 的相对分泌。 LS/IMM 和 RYGB 队列在基线时具有相似的空腹血清 FABP4 浓度。一年时，RYGB 受试者的平均血清 FABP4 下降了 42%（P = 0.002），但 LS/IMM 受试者的血清 FABP4 没有显着变化。在治疗组内或针对治疗组调整的多变量模型中，体重变化百分比并不是 12 个月 FABP4 的显着预测因子。在脂肪组织外植体中，FABP4在内脏和皮下脂肪组织之间的分泌类似。 T2DM 患者在 RYGB 后，FABP4 在手术后 12 个月减少，但在 LS/IMM 后没有减少。皮下和内脏脂肪组织外植体之间的 FABP4 分泌类似。患有 2 型糖尿病的肥胖患者进行 Roux-en Y 胃绕道手术后，血清 FABP4 降低。这一发现的重要性在于，FABP4 与心血管风险相关，可能有助于了解减肥手术的益处。
Serum concentrations of fatty acid binding proteins 4 (FABP4), an adipose tissue fatty acid chaperone, have been correlated with insulin resistance and cardiovascular risk factors. The objective of this study are to: (1) To assess relationships between Roux-en-Y gastric bypass (RYGB), intensive lifestyle modification and medical management protocol (LS/IMM), FABP4, and metabolic parameters in obese patients with severe type 2 diabetes mellitus (T2DM). (2) To evaluate the relative contribution of abdominal subcutaneous adipose and visceral adipose to the secretion of FABP4. Subjects were randomized to LS/IMM (n = 29) or to LS/IMM augmented with RYGB (n = 34). Relationships between FABP4 versus demographics, metabolic parameters, and 12-month changes in these values were examined. Visceral and subcutaneous adipose tissue explants from obese non-diabetic patients (n=5) were obtained and treated with forskolin to evaluate relative secretion of FABP4 in the different adipose tissue depots. The LS/IMM and RYGB cohorts had similar fasting serum FABP4 concentrations at baseline. At one year, mean serum FABP4 decreased by 42% in RYGB subjects (P = 0.002), but did not change significantly in LS/IMM. Percent weight change was not a significant predictor of 12-month FABP4 within treatment arm or in multivariate models adjusted for treatment arm. In adipose tissue explants, FABP4 was secreted similarly between visceral and subcutaneous adipose tissue. Following RYGB, FABP4 is reduced 12 months after surgery but not after LS/IMM in patients with T2DM. FABP4 was secreted similarly between subcutaneous and visceral adipose tissue explants. Serum FABP4 is decreased after Roux-en Y gastric bypass in obese patients with type 2 diabetes. The importance of this finding is that FABP4, which correlates with cardiovascular risk, may provide insight to the benefits of bariatric surgery.
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影响因子：
5
作者：
Camargo, Antonio;Meneses, Maria E.;Lopez-Miranda, Jose
通讯作者：
Lopez-Miranda, Jose
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1001/jama.2014.732
发表时间：
2014-02-26
期刊：
JAMA
影响因子：
--
作者：
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通讯作者：
Flegal KM
影响因子：
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作者：
Burak, M. Furkan;Inouye, Karen E.;Hotamisligil, Goekhan S.
通讯作者：
Hotamisligil, Goekhan S.
影响因子：
6.9
作者：
Engl, Julia;Ciardi, Christian;Ebenbichler, Christoph F.
通讯作者：
Ebenbichler, Christoph F.