Electronic nicotine delivery systems: a research agenda.
Electronic nicotine delivery systems: a research agenda.
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DOI：
10.1136/tc.2010.042168
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发表时间：
2011-05
期刊：
影响因子：
5.2
通讯作者：
Eissenberg T
中科院分区：
文献类型：
--
作者：
Etter JF;Bullen C;Flouris AD;Laugesen M;Eissenberg T
电子尼古丁输送系统（ENDS，也称为电子香烟或电子烟）用于通过吸入输送尼古丁，有时还输送其他物质。一些吸烟者报告说，他们使用ENDS作为戒烟辅助。无论是作为烟草产品还是作为药物输送装置销售，这些产品都需要受到监管，到目前为止，各国和各州都采取了各种监管措施，从没有监管到完全禁止。这些监管决策的经验基础是不确定的，必须对ENDS进行更多的研究，以确保监管机构，医疗保健提供者和消费者的决策是基于科学的。然而，对这些产品缺乏科学研究，包括安全性，滥用责任和戒烟效果。作者涵盖了从基础科学到公共卫生的广泛科学专业知识，建议非临床，临床和公共卫生研究的研究优先事项。他们的结论是，首要任务是描述这些产品的安全性，包括长期使用者的安全性。如果这些产品被证明是安全的，那么它们作为戒烟辅助剂的功效应该在适当设计的试验中进行测试。在进行这些研究之前，持续的营销构成了一个不受控制的实验，主要的结局指标是用户健康，评估不佳。这项研究工作有助于提高新戒烟设备的安全性和有效性，并有助于消除危险产品，可能会挽救许多生命。
Electronic nicotine delivery systems (ENDS, also called electronic cigarettes or e-cigarettes) are marketed to deliver nicotine and sometimes other substances by inhalation. Some tobacco smokers report that they used ENDS as a smoking cessation aid. Whether sold as tobacco products or drug delivery devices, these products need to be regulated, and thus far, across countries and states, there has been a wide range of regulatory responses ranging from no regulation to complete bans. The empirical basis for these regulatory decisions is uncertain, and more research on ENDS must be conducted in order to ensure that the decisions of regulators, health care providers and consumers are based on science. However, there is a dearth of scientific research on these products, including safety, abuse liability and efficacy for smoking cessation. The authors, who cover a broad range of scientific expertise, from basic science to public health, suggest research priorities for non-clinical, clinical and public health studies. They conclude that the first priority is to characterize the safety profile of these products, including in long-term users. If these products are demonstrated to be safe, their efficacy as smoking cessation aids should then be tested in appropriately designed trials. Until these studies are conducted, continued marketing constitutes an uncontrolled experiment and the primary outcome measure, poorly assessed, is user health. Potentially, this research effort, contributing to the safety and efficacy of new smoking cessation devices and to the withdrawal of dangerous products, could save many lives.
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影响因子：
3.4
作者：
Houtsmuller, EJ;Henningfield, JE;Stitzer, ML
通讯作者：
Stitzer, ML
影响因子：
5.2
作者：
Bullen, C.;McRobbie, H.;Laugesen, M.
通讯作者：
Laugesen, M.
影响因子：
39.2
作者：
Anthonisen, NR;Skeans, MA;Connett, JE
通讯作者：
Connett, JE
影响因子：
3.8
作者：
Cahn, Zachary;Siegel, Michael
通讯作者：
Siegel, Michael
DOI：
10.1158/1055-9965.epi-09-0654
发表时间：
2009-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hatsukami DK;Hanson K;Briggs A;Parascandola M;Genkinger JM;O'Connor R;Shields PG
通讯作者：
Shields PG