Intracellular lipid surveillance: Modulating protein dynamics through lipid sensing.
Intracellular lipid surveillance: Modulating protein dynamics through lipid sensing.
复制标题
DOI：
10.1002/ctm2.1147
复制
发表时间：
2022-12
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
脂质在几乎所有的生物过程中都扮演着基本的角色。虽然这类大分子是膨胀和复杂的，但脂质在细胞中的作用可以限制为三个主要功能：膜组成、信号传递和能量储备。在细胞膜和细胞膜中，脂类提供结构完整性、成分特异性和区隔作用。在维持细胞和代谢动态平衡的过程中，脂源性激素在促进生长发育的信号转导通路中起着调节配体的作用。1类固醇类脂，胆固醇，既是重要的膜成分，也是大多数类固醇激素的前体。2涉及血脂调节的值得注意的发现包括通过类固醇调节元件结合蛋白(SREBP)识别和表征胆固醇感知，该蛋白将类固醇的可利用性与膜成分和类固醇的生成联系在一起。3当胆固醇供应受限时，SREBP促进脂肪生成，增加类固醇的产生，恢复膜的流动性。这一开创性的发现开启了我们对类固醇脂类感知的理解，并代表了调节脂类可用性的第一个分子机制。然而，细胞如何在保持能量储备的情况下测量其脂质的可用性仍然是一个重要而悬而未决的问题。具体地说，目前还不清楚饥饿的细胞是如何
Lipids play fundamental roles in nearly all biological processes. While this class of macromolecules is expansive and complex, lipid roles in the cell can be confined to three major functions: membrane composition, signalling and energetic reserve. In cellular and organellular membranes, lipids provide structural integrity, compositional specificity and compartmentalisation. In the maintenance of cellular and metabolic homeostasis, lipid-derived hormones serve as regulatory ligands in signal transduction pathways that promote growth and development. 1 The sterol lipid, cholesterol, serves as both an important membrane component and the precursor for most steroid hormones. 2 Noteworthy discoveries involving the regulation of lipids include the identification and characterisation of cholesterol sensing through the sterol regulatory element binding protein (SREBP), which couples sterol availability with membrane composition and steroidogenesis. 3 When cholesterol availability is limited, SREBP promotes lipogenesis to increase sterol production and restore membrane fluidity. This seminal discovery initiated our understanding of sterol lipid sensing and represented the first molecular mechanism for regulating lipid availability. However, how cells measure their lipid availability in the context of maintaining energetic reserves remains an important yet outstanding question. Specifically, it was unclear how a starving cell
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9.8
作者：
Van Gilst MR;Hadjivassiliou H;Jolly A;Yamamoto KR
通讯作者：
Yamamoto KR
影响因子：
14.5
作者：
Jeong, Seong Ho;Lee, Hye Sun;Lee, Phil Hyu
通讯作者：
Lee, Phil Hyu
影响因子：
16.6
作者：
Walther TC;Farese RV Jr
通讯作者：
Farese RV Jr
影响因子：
4.6
作者：
Ronzier, Elsa;Parks, Xiaorong Xu;Lopes, Coeli M.
通讯作者：
Lopes, Coeli M.