mTOR-Mediated Cell Death and Infection
mTOR-Mediated Cell Death and Infection
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mTOR 介导的细胞死亡和感染
DOI：
10.1097/im9.0000000000000063
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Su Bing
中科院分区：
文献类型：
--
作者：
Li Song;Wang Qijun;Su Bing
病原体和宿主之间的战斗是一个持续的现象，已经研究了几个世纪。尽管多细胞生物已经发展出复杂的免疫系统来防御病原体，但病原体通常能够成功感染宿主。为了提高生存机会，病原体可以劫持宿主的新陈代谢，这是可能影响感染的关键控制点。哺乳动物雷帕霉素靶点（mTOR）是先天和适应性免疫中营养传感器和代谢的中央调节器雷帕霉素作为一种针对mTOR通路的药物，已广泛应用于临床数十年，且相对安全。然而，长期服用雷帕霉素后会出现一些意想不到的感染，表明mTOR信号通路与感染过程之间存在着密切的关系。本文简要回顾了mTOR通路以及雷帕霉素目前的临床应用情况，并总结了mTOR通路在免疫细胞死亡中的作用，包括细胞凋亡、坏死性凋亡、焦亡和铁死亡及其对抗感染免疫的影响。最后，讨论了mTOR抑制剂在2019冠状病毒病临床治疗中的潜在应用。
The battle between pathogens and hosts is an ongoing phenomenon that has been studied for centuries.Although multicellular organisms have developed sophisticated immune systems to defend against pathogens,pathogens are often able to successfully infect their hosts.To enhance their chance of survival,pathogens can hijack the host's metabolism,which serves as a critical control point that can potentially impact infections.Mammalian target of rapamycin (mTOR) is the nutrient sensor and central regulator of metabolism in innate and adaptive immune cells.Rapamycin,a drug targeting the mTOR pathway,has been widely used in clinical practice for decades and is relatively safe.However,some unexpected infections occur after long-term administration of rapamycin,indicating the presence of a close relationship between mTOR signaling and the infection process.In this manuscript,we briefly review the mTOR pathway and the current clinical use of rapamycin;we also summarize the role of the mTOR pathway in immune cell death,including apoptosis,necroptosis,pyroptosis,and ferroptosis,and its impact on anti-infection immunity.Finally,potential application of mTOR inhibitor in coronavirus disease 2019 clinical therapy is discussed.
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影响因子：
11.4
作者：
Oh, Won Jun;Wu, Chang-chih;Jacinto, Estela
通讯作者：
Jacinto, Estela
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
DOI：
10.1038/nri3901
发表时间：
2015-10
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Weichhart T;Hengstschläger M;Linke M
通讯作者：
Linke M
DOI：
10.1038/nrneph.2016.108
发表时间：
2016-10
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Fantus D;Rogers NM;Grahammer F;Huber TB;Thomson AW
通讯作者：
Thomson AW
影响因子：
7.3
作者：
Keating R;McGargill MA
通讯作者：
McGargill MA