Bayesian analysis of additive epistasis arising from new mutations in mice.
Bayesian analysis of additive epistasis arising from new mutations in mice.
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对小鼠新突变引起的加性上位性的贝叶斯分析。
DOI：
10.1017/s001667231400010x
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发表时间：
2014
影响因子：
1.5
通讯作者：
Medrano,JuanF
中科院分区：
文献类型：
--
作者：
Casellas,Joaquim;Gianola,Daniel;Medrano,JuanF
几项针对具有近交遗传背景的实验室物种的研究报告了多基因附加突变变异的持续上传。这些研究集中于新突变的直接贡献，而没有考虑新突变与先前存在的多态性相互作用所产生的上位效应的可能性。在这项工作中，我们重点关注这一主题，并分析了两个近交小鼠群体 9 周体重上位方差的统计和生物学相关性。我们开发了一种新的线性混合模型参数化，其中在贝叶斯设计下考虑了与创始人相关的加性遗传变异性、加性突变变异性以及两个变异源之间的相互作用项，并且不需要上位遗传协方差矩阵的反转。分析重点关注 C57BL/6J 小鼠 (n = 3736) 的六代数据集和 C57BL/6Jhg/hg 小鼠 (n = 2843) 的五代数据集。偏差信息标准 (DIC) 显然有利于解释上位变异的模型，两个群体中的减少量均大于 50 DIC 单位。创始人相关、突变和上位遗传力的模态估计在 C57BL/6J 中为 0·068、0·011 和 0·095，在 C57BL/6Jhg/hg 中为 0·060、0·010 和 0·113，排除了对源自小鼠新突变的上位性的生物学相关性的任何疑问。这些结果为哺乳动物遗传结构中上位性的相关性提供了新的见解，并作为实验室小鼠近交系遗传异质性的另一个来源的重要组成部分。
The continuous uploading of polygenic additive mutational variability has been reported in several studies in laboratory species with an inbred genetic background. These studies have focused on the direct contribution of new mutations without considering the possibility of epistatic effects derived from the interaction of new mutations with pre-existing polymorphisms. In this work we focused on this main topic and analysed the statistical and biological relevance of the epistatic variance for 9 week body weight in two populations of inbred mice. We developed a new linear mixed model parameterization where founder-related additive genetic variability, additive mutational variability and the interaction terms between both sources of variation were accounted for under a Bayesian design and without requiring the inversion of a matrix of epistatic genetic covariances. The analyses focused on a six-generations data set from C57BL/6J mice (n = 3736) and a five-generations data set from C57BL/6Jhg/hg mice (n = 2843). The deviance information criterion (DIC) clearly favoured the model accounting for epistatic variability with reductions larger than 50 DIC units in both populations. Modal estimates for founder related, mutational and epistatic heritabilities were 0·068, 0·011 and 0·095 in C57BL/6J and 0·060, 0·010 and 0·113 in C57BL/6Jhg/hg , ruling out any doubt about the biological relevance of epistasis originating from new mutations in mice. These results contribute new insights on the relevance of epistasis in the genetic architecture of mammals and serve as an important component of an additional source of genetic heterogeneity for inbred strains of laboratory mice.
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动物育种中的贝叶斯争议。
影响因子：
3.3
作者：
Agustín Blasco
通讯作者：
Agustín Blasco
使用线性和非线性模型对绵羊离散繁殖性状进行遗传分析：II。
影响因子：
3.3
作者：
C. Matos;D. L. Thomas;D. Gianola;Miguel Pérez;L. D. Young
通讯作者：
L. D. Young
南非安哥拉山羊客观和主观羊毛性状和体重的重复性和遗传力
影响因子：
1.8
作者：
M. Snyman;J. J. Olivier
通讯作者：
J. J. Olivier
影响因子：
3.3
作者：
Casellas, Joaquim;Medrano, Juan R.
通讯作者：
Medrano, Juan R.
DOI：
10.1186/1297-9686-37-3-151
发表时间：
2005-03
期刊：
Genetics, selection, evolution : GSE
影响因子：
--
作者：
Leamy LJ;Elo K;Nielsen MK;Dale Van Vleck L;Pomp D
通讯作者：
Pomp D