Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment and Dementia.
Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment and Dementia.
复制标题
DOI：
10.1161/jaha.123.030925
复制
发表时间：
2023-09-05
影响因子：
5.4
通讯作者：
中科院分区：
文献类型：
--
作者：
与非西班牙裔白人成年人相比，非西班牙裔黑人成年人患血管性认知障碍和阿尔茨海默病及相关痴呆的比例较高，这可能是由于脑小血管疾病负担以及阿尔茨海默病和相关痴呆的风险等位基因存在差异。我们在这里描述了 REGARDS（卒中地理和种族差异的原因）研究的辅助研究方法，该研究将检查脑小血管疾病和血管的磁共振成像标记物的作用，以及阿尔茨海默病和相关痴呆的遗传危险因素在非西班牙裔白人和非西班牙裔黑人参与者血管性认知障碍和痴呆的患病率和轨迹的种族差异中的作用。对于既往没有中风病史但在参加研究后发生中风或短暂性脑缺血发作的参与者，将使用神经影像学国际共识标准上的血管变化报告标准和用于量化脑小血管疾病的自动分析流程来评估磁共振成像扫描。参与者将对阿尔茨海默病和相关痴呆症的 APOE ε4 和 TREM2 风险等位基因进行基因分型。 6 项筛选将定义整体认知功能并成为主要认知结果。至少有 426 名非西班牙裔黑人和 463 名非西班牙裔白人参与者至少进行过 2 次中风或短暂性脑缺血发作前认知评估和 2 次后中风或短暂性脑缺血发作认知评估，我们将至少有 80% 的功效来检测 Z 评分 0.09 SD 变化的最小效应大小，并校正多达 20 次测试（即，在调整最多 20 个协变量后，P<0.0025）认知能力下降。
Non‐Hispanic Black adults have a higher proportion of vascular cognitive impairment and Alzheimer's disease and related dementias compared with non‐Hispanic White adults that may be due to differences in the burden of cerebral small vessel disease and risk alleles for Alzheimer's disease and related dementias. We describe here the methods of an ancillary study to the REGARDS (Reason for Geographic and and Racial Difference in Stroke) study, which will examine the role of magnetic resonance imaging markers of cerebral small vessel disease and vascular as well as genetic risk factors for Alzheimer's disease and related dementias in racial disparity in the prevalence and trajectory of vascular cognitive impairment and dementia in non‐Hispanic White and non‐Hispanic Black participants. In participants with no prior history of stroke who had an incident stroke or transient ischemic attack after enrollment in the study, magnetic resonance imaging scans will be evaluated using the Standards for Reporting Vascular Changes on Neuroimaging international consensus criteria and automated analysis pipelines for quantification of cerebral small vessel disease. Participants will be genotyped for APOE ε4 and TREM2 risk alleles for Alzheimer's disease and related dementias. The 6‐item screener will define global cognitive function and be the primary cognitive outcome. With at least 426 non‐Hispanic Black and 463 non‐Hispanic White participants who have at least 2 prior and 2 poststroke or transient ischemic attack cognitive assessments, we will have at least 80% power to detect a minimum effect size of 0.09 SD change in Z score, with correction for as many as 20 tests (ie, at P<0.0025, after adjusting for up to 20 covariates) for cognitive decline.
DOI：
10.3390/ijerph20031885
发表时间：
2023-01-19
影响因子：
--
作者：
Cohn-Schwartz, Ella;Joshi, Rennie;McClure, Leslie A
通讯作者：
McClure, Leslie A
影响因子：
4
作者：
Staszewski J;Piusińska-Macoch R;Brodacki B;Skrobowska E;Macek K;Stępień A
通讯作者：
Stępień A
影响因子：
--
作者：
Wilson, Robert S.;Leurgans, Sue E.;Foroud, Tatiana M.;Sweet, Robert A.;Graff-Radford, Neill;Mayeux, Richard;Bennett, David A.
通讯作者：
Bennett, David A.